In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice

被引：56

作者：

Giacchino, J

Criado, JR

Games, D

Henriksen, S

机构：

[1] Scripps Res Inst, Dept Neuropharmacol CVN 13, La Jolla, CA 92037 USA

[2] Elan Pharmaceut, S San Francisco, CA 94080 USA

来源：

BRAIN RESEARCH | 2000年 / 876卷 / 1-2期

关键词：

amyloid precursor protein; Alzheimer's disease; long-term potentiation; paired-pulse facilitation; hippocampus; dentate gyrus;

D O I：

10.1016/S0006-8993(00)02615-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive impairment. We examined in vivo alterations in hippocampal neurotransmission in both young and aged PDAPP transgenic mice and nontransgenic littermates. We now report that in vivo abnormal neurotransmission in hippocampal circuits of PDAPP mice precedes beta deposition and neurodegeneration. These in vivo data provide the first evidence that dysfunction in hippocampal neuronal circuits may not be correlated with age-related extracellular beta plaque deposition. (C) 2000 Elsevier Science B.V. All rights reserved.

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页码：185 / 190

页数：6

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