The enemy within: dormant retroviruses awaken

被引：17
作者：
Engel, Michael E. [1 ,2 ,3 ]
Hiebert, Scott W. [4 ]
机构：
[1] Vanderbilt Univ, Sch Med, Monroe Carell Jr Childrens Hosp, Dept Pediat, Nashville, TN 37212 USA
[2] Vanderbilt Univ, Sch Med, Monroe Carell Jr Childrens Hosp, Dept Canc Biol, Nashville, TN 37212 USA
[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA
[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA
来源：
NATURE MEDICINE | 2010年 / 16卷 / 05期
关键词：
GENE;
D O I：
10.1038/nm0510-517
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation-but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571-579).
引用
收藏
页码：517 / 518
页数：2
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