SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines

被引：151

作者：

Shen, Xiaoying ^{[1
,2
]}

Tang, Haili ^{[1
]}

McDanal, Charlene ^{[1
]}

Wagh, Kshitij ^{[3
]}

Fischer, William ^{[3
]}

Theiler, James ^{[3
]}

Yoon, Hyejin ^{[3
]}

Li, Dapeng ^{[2
]}

Haynes, Barton F. ^{[2
,6
]}

Sanders, Kevin O. ^{[1
,2
]}

Gnanakaran, Sandrasegaram ^{[3
]}

Hengartner, Nick ^{[3
]}

Pajon, Rolando ^{[4
]}

Smith, Gale ^{[5
]}

Glenn, Gregory M. ^{[5
]}

Korber, Bette ^{[3
]}

Montefiori, David C. ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Surg, Sch Med, Durham, NC 27708 USA

[2] Duke Univ, Duke Human Vaccine Inst, Sch Med, Durham, NC 27708 USA

[3] Los Alamos Natl Lab, Theoret Biol & Biophys, Los Alamos, NM USA

[4] Moderna Inc, Cambridge, MA USA

[5] Novavax Inc, Gaithersburg, MD USA

[6] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

来源：

CELL HOST & MICROBE | 2021年 / 29卷 / 04期

基金：

美国国家卫生研究院;

关键词：

VIVO;

D O I：

10.1016/j.chom.2021.03.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

All current vaccines for COVID-19 utilize ancestral SARS-CoV-2 spike with the goal of generating protective neutralizing antibodies. The recent emergence and rapid spread of several SARS-CoV-2 variants carrying multiple spike mutations raise concerns about possible immune escape. One variant, first identified in the United Kingdom (B.1.1.7, also called 20I/501Y.V1), contains eight spike mutations with potential to impact antibody therapy, vaccine efficacy, and risk of reinfection. Here, we show that B.1.1.7 remains sensitive to neutralization, albeit at moderately reduced levels (similar to sim;2-fold), by serum samples from convalescent individuals and recipients of an mRNA vaccine (mRNA-1273, Moderna) and a protein nanoparticle vaccine (NVX-CoV2373, Novavax). A subset of monoclonal antibodies to the receptor binding domain (RBD) of spike are less effective against the variant, while others are largely unaffected. These findings indicate that variant B.1.1.7 is unlikely to be a major concern for current vaccines or for an increased risk of reinfection.

引用

页码：529 / +

页数：14

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