A novel perivascular cell population in the zebrafish brain

被引：80

作者：

Galanternik, Marina Venero ^{[1
]}

Castranova, Daniel ^{[1
]}

Gore, Aniket V. ^{[1
]}

Blewett, Nathan H. ^{[1
]}

Jung, Hyun Min ^{[1
]}

Stratman, Amber N. ^{[1
]}

Kirby, Martha R. ^{[2
]}

Iben, James ^{[1
]}

Miller, Mayumi F. ^{[1
]}

Kawakami, Koichi ^{[3
,4
]}

Maraia, Richard J. ^{[1
]}

Weinstein, Brant M. ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Div Dev Biol, Bethesda, MD 20892 USA

[2] NHGRI, NIH, Translat & Funct Genom Branch, Bethesda, MD 20892 USA

[3] Natl Inst Genet, Div Mol & Dev Biol, Mishima, Shizuoka, Japan

[4] Grad Univ Adv Studies, Dept Genet, SOKENDAI, Mishima, Shizuoka, Japan

来源：

ELIFE | 2017年 / 6卷

基金：

日本学术振兴会;

关键词：

GRANULAR PERITHELIAL CELLS; CENTRAL-NERVOUS-SYSTEM; HEMATOPOIETIC STEM-CELLS; NEURAL CREST CELLS; CEREBRAL-CORTEX; FGP CELLS; LYMPHATIC ENDOTHELIUM; AORTIC ENDOTHELIUM; SCAVENGER RECEPTOR; MANNOSE RECEPTOR;

D O I：

10.7554/eLife.24369

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The blood-brain barrier is essential for the proper homeostasis and function of the CNS, but its mechanism of function is poorly understood. Perivascular cells surrounding brain blood vessels are thought to be important for blood-brain barrier establishment, but their roles are not well defined. Here, we describe a novel perivascular cell population closely associated with blood vessels on the zebrafish brain. Based on similarities in their morphology, location, and scavenger behavior, these cells appear to be the zebrafish equivalent of cells variably characterized as Fluorescent Granular Perithelial cells (FGPs), perivascular macrophages, or 'Mato Cells' in mammals. Despite their macrophage-like morphology and perivascular location, zebrafish FGPs appear molecularly most similar to lymphatic endothelium, and our imaging studies suggest that these cells emerge by differentiation from endothelium of the optic choroidal vascular plexus. Our findings provide the first report of a perivascular cell population in the brain derived from vascular endothelium.

引用

页数：28

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