Antibacterial effect of some benzopyrone derivatives

被引：46
作者：
Amin, Rehab [1 ]
Krammer, Barbara [2 ]
Abdel-Kader, Nora [3 ]
Verwanger, Thomas [2 ]
El-Ansary, Aida [3 ]
机构：
[1] Cairo Univ, Natl Inst Laser Enhanced Sci, Giza, Egypt
[2] Salzburg Univ, Dept Mol Biol, A-5020 Salzburg, Austria
[3] Cairo Univ, Fac Sci, Dept Chem, Cairo, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 01期
关键词：
Schiff base; Antibacterial effect; Escherichia coli; Staphylococcus capitis; ANTIMICROBIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; SCHIFF; COMPLEXES; AGENTS;
D O I：
10.1016/j.ejmech.2009.10.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The Schiff base derivatives of benzopyran-4-one are characterized by imine groups which have biological activities such as antimicrobial, antifungal and antitumoral. The aim of this study was therefore to evaluate the toxicity of Schiff bases towards bacterial cells. Escherichia coli as Gram-negative bacteria and Staphylococcus capitis as Gram-positive bacteria were exposed to different concentrations of Schiff bases. For assessment of toxicity a 96-well turbidimetric procedure, capable of testing the antimicrobial properties on a single microplate. was used. Analysis of the growth curves showed that the antibacterial effect of these Schiff bases on Gram-negative bacteria was higher than that on Gram-positive. Furthermore the presence of hydroxylic groups is correlated with an increased antibacterial effect. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：372 / 378
页数：7
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