Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment

被引：0
作者：
Wright, Joel G., Jr. [1 ]
Amin, Md Nafiz [2 ]
Meena, Gopikrishnan G. [2 ]
Schmidt, Holger [2 ]
Hawkins, Aaron R. [1 ]
机构：
[1] Brigham Young Univ, Dept Elect & Comp Engn, Provo, UT 84602 USA
[2] Univ Calif Santa Cruz, Sch Engn, Santa Cruz, CA 95064 USA
来源：
JOURNAL OF LIGHTWAVE TECHNOLOGY | 2021年 / 39卷 / 10期
关键词：
Optical waveguides; Fluorescence; Biosensors; Photonics; Biological system modeling; Predictive models; Transmission line matrix methods; Anti-resonant reflecting optical waveguides (ARROW); integrated waveguides; model design; optofluidics; predictive simulation; WAVE-GUIDES;
D O I：
10.1109/JLT.2021.3061872
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biological sample after tagging relevant DNA or RNA sequences. An overview of the biosensor geometry and fabrication processes is presented. The basis for the predictive model is also outlined. The model is then compared to experimental results for three different biosensor designs. The model is shown to have similar signal statistics as physical tests, illustrating utility as a pre-fabrication design tool and as a predictor of detection sensitivity.
引用
收藏
页码：3330 / 3340
页数：11
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