Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex

被引：161

作者：

Mohan, Hemanth ^{[1
]}

Verhoog, Matthijs B. ^{[1
]}

Doreswamy, Keerthi K. ^{[1
]}

Eyal, Guy ^{[2
,3
]}

Aardse, Romy ^{[1
]}

Lodder, Brendan N. ^{[1
]}

Goriounova, Natalia A. ^{[1
]}

Asamoah, Boateng ^{[1
]}

Brakspear, A. B. Clementine B. ^{[1
]}

Groot, Colin ^{[1
]}

van der Sluis, Sophie ^{[4
]}

Testa-Silva, Guilherme ^{[1
]}

Obermayer, Joshua ^{[1
]}

Boudewijns, Zimbo S. R. M. ^{[1
]}

Narayanan, Rajeevan T. ^{[1
]}

Baayen, Johannes C. ^{[5
]}

Segev, Idan ^{[2
,3
]}

Mansvelder, Huibert D. ^{[1
]}

de Kock, Christiaan P. J. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Integrat Neurophysiol, NL-1081 HV Amsterdam, Netherlands

[2] Hebrew Univ Jerusalem, Dept Neurobiol, IL-91904 Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-91904 Jerusalem, Israel

[4] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Sect Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam Med Ctr, Dept Neurosurg, NL-1081 HV Amsterdam, Netherlands

来源：

CEREBRAL CORTEX | 2015年 / 25卷 / 12期

关键词：

HUMAN CEREBRAL-CORTEX; QUANTITATIVE-ANALYSIS; SYNAPTIC INTEGRATION; CALRETININ NEURONS; PREFRONTAL CORTEX; SPINY STELLATE; CELLS; MORPHOLOGY; BRAIN; EVOLUTION;

D O I：

10.1093/cercor/bhv188

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The size and shape of dendrites and axons are strong determinants of neuronal information processing. Our knowledge on neuronal structure and function is primarily based on brains of laboratory animals. Whether it translates to human is not known since quantitative data on "full" human neuronal morphologies are lacking. Here, we obtained human brain tissue during resection surgery and reconstructed basal and apical dendrites and axons of individual neurons across all cortical layers in temporal cortex (Brodmann area 21). Importantly, morphologies did not correlate to etiology, disease severity, or disease duration. Next, we show that human L(ayer) 2 and L3 pyramidal neurons have 3-fold larger dendritic length and increased branch complexity with longer segments compared with temporal cortex neurons from macaque and mouse. Unsupervised cluster analysis classified 88% of human L2 and L3 neurons into human-specific clusters distinct from mouse and macaque neurons. Computational modeling of passive electrical properties to assess the functional impact of large dendrites indicates stronger signal attenuation of electrical inputs compared with mouse. We thus provide a quantitative analysis of "full" human neuron morphologies and present direct evidence that human neurons are not "scaled-up" versions of rodent or macaque neurons, but have unique structural and functional properties.

引用

页码：4839 / 4853

页数：15

共 71 条

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