Tinospora cordifolia ameliorates anxiety-like behavior and improves cognitive functions in acute sleep deprived rats

被引：58

作者：

Mishra, Rachana ^{[1
]}

Manchanda, Shaffi ^{[1
]}

Gupta, Muskan ^{[1
]}

Kaur, Taranjeet ^{[1
]}

Saini, Vedangana ^{[1
]}

Sharma, Anuradha ^{[1
]}

Kaur, Gurcharan ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Biotechnol, Med Biotechnol Lab, Amritsar 143005, Punjab, India

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

PRO-INFLAMMATORY CYTOKINES; LONG-TERM POTENTIATION; PSA-NCAM EXPRESSION; PARADOXICAL SLEEP; DEPRIVATION; BRAIN; INVOLVEMENT; FRAGMENTATION; NEUROGENESIS; ACTIVATION;

D O I：

10.1038/srep25564

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sleep deprivation (SD) leads to the spectrum of mood disorders like anxiety, cognitive dysfunctions and motor coordination impairment in many individuals. However, there is no effective pharmacological remedy to negate the effects of SD. The current study examined whether 50% ethanolic extract of Tinospora cordifolia (TCE) can attenuate these negative effects of SD. Three groups of adult Wistar female rats - (1) vehicle treated-sleep undisturbed (VUD), (2) vehicle treated-sleep deprived (VSD) and (3) TCE treated-sleep deprived (TSD) animals were tested behaviorally for cognitive functions, anxiety and motor coordination. TSD animals showed improved behavioral response in EPM and NOR tests for anxiety and cognitive functions, respectively as compared to VSD animals. TCE pretreatment modulated the stress induced-expression of plasticity markers PSA-NCAM, NCAM and GAP-43 along with proteins involved in the maintenance of LTP i.e., CamKII-alpha and calcineurin (CaN) in hippocampus and PC regions of the brain. Interestingly, contrary to VSD animals, TSD animals showed downregulated expression of inflammatory markers such as CD11b/c, MHC-1 and cytokines along with inhibition of apoptotic markers. This data suggests that TCE alone or in combination with other memory enhancing agents may help in managing sleep deprivation associated stress and improving cognitive functions.

引用

页数：15

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