The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor α2β1 and the two adhesive receptors then collaborate to fully activate platelets to form thrombi

被引：0
|
作者：
Chen, JM [1 ]
Whitelock, JL [1 ]
Morales, LD [1 ]
Lopez, JA [1 ]
Cruz, MA [1 ]
机构：
[1] Baylor Coll Med, Houston, TX 77030 USA
来源：
BLOOD | 2004年 / 104卷 / 11期
关键词：
D O I：
10.1182/blood.V104.11.1556.1556
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1556
引用
收藏
页码：434A / 435A
页数：2
相关论文
共 36 条
  • [1] The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor α2β1 to bind collagen:: activation-dependent conformational change of the α2-I domain
    Cruz, MA
    Chen, JM
    Whitelock, JL
    Morales, LD
    López, JA
    BLOOD, 2005, 105 (05) : 1986 - 1991
  • [2] Identification of a Small Molecule That Modulates Platelet Glycoprotein Ib-von Willebrand Factor Interaction
    Broos, Katleen
    Trekels, Mieke
    Jose, Rani Alphonsa
    Demeulemeester, Jonas
    Vandenbulcke, Aline
    Vandeputte, Nele
    Venken, Tom
    Egle, Brecht
    De Borggraeve, Wim M.
    Deckmyn, Hans
    De Maeyer, Marc
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (12) : 9461 - 9472
  • [3] Platelet thrombus formation on collagen at high shear rates is mediated by von Willebrand factor-glycoprotein Ib interaction and inhibited by von Willebrand factor-glycoprotein IIb/IIIa interaction
    Wu, YP
    Vink, T
    Schiphorst, M
    van Zanten, GH
    IJsseldijk, MJW
    de Groot, PG
    Sixma, JJ
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) : 1661 - 1667
  • [4] Purified A2 domain of von Willebrand factor binds to the active conformation of von Willebrand factor and blocks the interaction with platelet glycoprotein Ibα
    Martin, C.
    Morales, L. D.
    Cruz, M. A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (07) : 1363 - 1370
  • [5] Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase
    Wu, Y
    Asazuma, N
    Satoh, K
    Yatomi, Y
    Takafuta, T
    Berndt, MC
    Ozaki, Y
    BLOOD, 2003, 101 (09) : 3469 - 3476
  • [6] Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ib alpha
    Miyata, S
    Goto, S
    Federici, AB
    Ware, J
    Ruggeri, ZM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) : 9046 - 9053
  • [7] The antithrombotic effect of the fucoidan of Lessonia vadosa: a strong inhibitor of the platelet glycoprotein IB receptor - von Willebrand factor interaction
    Broos, K.
    De Borggraeve, W.
    Vandenbulcke, A.
    Vandeputte, N.
    De Ceunynck, K.
    Chandia, N. P.
    Matsuhiro, B. Y.
    Vanhoorelbeke, K.
    Deckmyn, H.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 289 - 289
  • [8] STRUCTURES OF PLATELET-RECEPTOR GLYCOPROTEIN Ib AND ITS COMPLEX WITH VON WILLEBRAND FACTOR DOMAIN A1
    Huizinga, E. G.
    Tsuji, S.
    Romijn, R. A. P.
    Schiphorst, M. E.
    de Groot, Ph. G.
    Sixma, J. J.
    Gros, P.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2002, 58 : C238 - C238
  • [9] Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor γ-chain, Fyn, and Lyn to activate human platelets
    Falati, S
    Edmead, CE
    Poole, AW
    BLOOD, 1999, 94 (05) : 1648 - 1656
  • [10] O-linked glycans mediate the interaction of von Willebrand factor with platelet receptor glycoprotein IB under shear conditions
    Nowak, A.
    Laffan, M.
    Mckinnon, T.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 736 - 736
1234