Evaluation of nanogels as supports for enzyme immobilization

被引：28

作者：

Chauhan, Ghanshyam S. ^{[1
]}

机构：

[1] Himachal Pradesh Univ, Dept Chem, Shimla 171005, Himachal Prades, India

来源：

POLYMER INTERNATIONAL | 2014年 / 63卷 / 11期

关键词：

stimuli-responsive nanogels; enzyme loading; covalent immobilization; single enzyme nanogel; solvent and thermal stability; immobilized therapeutic enzymes; SELF-ASSEMBLED NANOGELS; SINGLE-ENZYME; MAGNETIC NANOGELS; CARBOXYL GROUPS; LIPASE NANOGEL; NANOPARTICLES; STABILITY; DELIVERY; CHYMOTRYPSIN; TEMPERATURE;

D O I：

10.1002/pi.4734

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Nanogels are hydrophilic polymers made up of crosslinked nano-sized particles. These nanogels have large surface area that offers several functional groups as reserves for binding drugs, generating biosensors and as supports for enzyme immobilization. This mini-review is an attempt to evaluate the recent developments in the use of nanogels as supports in enzyme immobilization. Emphasis is laid on the effect of nanogel structure and immobilization protocol on the property profile of the immobilized enzymes as compared with their free counterparts. The prospective applications of the nanogel-immobilized enzymes are also evaluated. (c) 2014 Society of Chemical Industry

引用

页码：1889 / 1894

页数：6

共 54 条

[1] Self-assembled nanogels of cholesteryl-modified polysaccharides: Effect of the polysaccharide structure on their association characteristics in the dilute and semidilute regimes [J].

Akiyama, Eri ;

Morimoto, Nobuyuki ;

Kujawa, Piotr ;

Ozawa, Yayoi ;

Winnik, Francoise M. ;

Akiyoshit, Kazunari .

BIOMACROMOLECULES, 2007, 8 (08) :2366-2373

[2] Covalently incorporated protein-nanogels using AGET ATRP in an inverse miniemulsion [J].

Averick, Saadyah E. ;

Magenau, Andrew J. D. ;

Simakova, Antonina ;

Woodman, Bradley F. ;

Seong, Andrew ;

Mehl, Ryan A. ;

Matyjaszewski, Krzysztof .

POLYMER CHEMISTRY, 2011, 2 (07) :1476-1478

[3] A macrophage-nanozyme delivery system for Parkinson's disease [J].

Batrakova, Elena V. ;

Li, Shu ;

Reynolds, Ashley D. ;

Mosley, R. Lee ;

Bronich, Tatiana K. ;

Kabanov, Alexander V. ;

Gendelman, Howard E. .

BIOCONJUGATE CHEMISTRY, 2007, 18 (05) :1498-1506

[4] Acidic pH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles [J].

Deka, Smriti R. ;

Quarta, Alessandra ;

Di Corato, Riccardo ;

Falqui, Andrea ;

Manna, Liberato ;

Cingolani, Roberto ;

Pellegrino, Teresa .

LANGMUIR, 2010, 26 (12) :10315-10324

[5]

Dharela R, 2013, CURR CATAL, V2, P225

[6]

Dharela R., 2013, CURR CATAL, V2, P122

[7] Temperature-Triggered Enzyme Immobilization and Release Based on Cross-Linked Gelatin Nanoparticles [J].

Gan, Zhenhai ;

Zhang, Ting ;

Liu, Yongchun ;

Wu, Daocheng .

PLOS ONE, 2012, 7 (10)

[8] Molecular Fundamentals of Enzyme Nanogels [J].

Ge, Jun ;

Lu, Diannan ;

Wang, Jun ;

Yan, Ming ;

Lu, Yunfeng ;

Liu, Zheng .

JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (45) :14319-14324

[9] Bovine Serum Albumin-Poly(methyl methacrylate) Nanoparticles: An Example of Frustrated Phase Separation [J].

Ge, Jun ;

Lei, Jiandu ;

Zare, Richard N. .

NANO LETTERS, 2011, 11 (06) :2551-2554

[10]

Ge J, 2011, METHODS MOL BIOL, V743, P119, DOI 10.1007/978-1-61779-132-1_10

← 1 2 3 4 5 6 →