Mass Spectrometry Imaging in Oncology Drug Discovery

被引：44

作者：

Goodwin, R. J. A. ^{[1
]}

Bunch, J. ^{[2
,3
]}

McGinnity, D. F. ^{[4
]}

机构：

[1] AstraZeneca, Mass Spectrometry Imaging Grp, Pathol Sci Drug Safety & Metab, Innovat Med & Early Dev, Cambridge, England

[2] Natl Phys Lab, Teddington, Middx, England

[3] Univ Nottingham, Sch Pharm, Nottingham, England

[4] AstraZeneca, DMPK, Oncol IMED, Innovat Med & Early Dev, Cambridge, England

来源：

APPLICATIONS OF MASS SPECTROMETRY IMAGING TO CANCER | 2017年 / 134卷

关键词：

DESORPTION ELECTROSPRAY-IONIZATION; BLOOD-BRAIN-BARRIER; PROTEIN-KINASE-B; BREAST-CANCER; MALDI-MS; SPATIAL-DISTRIBUTION; SAMPLE PREPARATION; HIGH-RESOLUTION; TISSUE MARKERS; MURINE BRAIN;

D O I：

10.1016/bs.acr.2016.11.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the last decade mass spectrometry imaging (MSI) has been integrated in to many areas of drug discovery and development. It can have significant impact in oncology drug discovery as it allows efficacy and safety of compounds to be assessed against the backdrop of the complex tumour microenvironment. We will discuss the roles of MSI in investigating compound and metabolite biodistribution and defining pharma-cokinetic -pharmacodynamic relationships, analysis that is applicable to all drug discovery projects. We will then look more specifically at how MSI can be used to understand tumour metabolism and other applications specific to oncology research. This will all be described alongside the challenges of applying MSI to industry research with increased use of metrology for MSI.

引用

收藏

页码：133 / 171

页数：39

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