The CD28T-cell costimulatory molecule was shown to regulate in vivo migration of memory T cells independent of TCR stimulation, suggesting that CD28 can have additional functions beyond costimulation. However, the mechanism involved, the physiological relevance, and the therapeutic implications await further investigation.
机构:
Univ Penn, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USAUniv Penn, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
Riley, JL
June, CH
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机构:
Univ Penn, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USAUniv Penn, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA