The role of genetic predisposition in the development of cardiovascular diseases (myocardial infarction, ischemic stroke, unstable stenocardia) and its interaction with conventional risk factors

被引：0
作者：
Nazarenko, G. I. [1 ]
Skvortsova, V. I. [1 ]
Kleimenova, E. B. [1 ]
Konstantinova, M. V. [1 ]
机构：
[1] Russian State Med Univ, Res Inst Stroke, Med Ctr Bank Russia, Moscow 117437, Russia
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2009年 / 109卷 / 10期
关键词：
cardiovascular diseases; risk factors; molecular-genetic markers; APOE; ACE; MTHFR (C677T); CORONARY-HEART-DISEASE; POLYMORPHISM; ASSOCIATION; ATHEROSCLEROSIS; METAANALYSIS; GENOTYPES;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To assess the risk of cardiovascular events, the diagnostic effectiveness of molecular-genetic markers (polymorphisms in APOE, ACE I/D) and MTHFR (C677T) genes) in combination with conventional risk factors has been studied. The prognostic effectiveness of common algorithms (the Framingham scale) is not sufficient for evaluation of risk factors for cardiovascular diseases. The combination of results of molecular-genetic testing with conventional risk factors allows to increase the predictability of cardiovascular risks.
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页码：19 / 25
页数：7
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