Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear. Recent findings have shown that oxidative stress, inflammation, and glutamatergic pathways play key roles in the causes of OCD. However, first-line therapies include cognitive-behavioral therapy but only 40% of the patients respond to this first-line therapy. Research for new treatment is mandatory. This review focuses on the potential effects of cannabidiol (CBD), as a potential therapeutic strategy, on OCD and some of the presumed mechanisms by which CBD provides its benefit properties. CBD medication downregulates GSK-3 beta, the main inhibitor of the WNT/beta-catenin pathway. The activation of the WNT/beta-catenin could be associated with the control of oxidative stress, inflammation, and glutamatergic pathway and circadian rhythms dysregulation in OCD. Future prospective clinical trials could focus on CBD and its different and multiple interactions in OCD.
机构:
Department of Clinical Research and Innovation (DRCI), Foch Hospital
2. Centre de Recherche Clinique,Grand H?pital de l'Est Francilien(GHEF)Department of Clinical Research and Innovation (DRCI), Foch Hospital
2. Centre de Recherche Clinique,Grand H?pital de l'Est Francilien(GHEF)
Alexandre Vallée
Yves Lecarpentier
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机构:
Laboratoire de Mathématiques et Applications(LMA),Université de PoitiersDepartment of Clinical Research and Innovation (DRCI), Foch Hospital
2. Centre de Recherche Clinique,Grand H?pital de l'Est Francilien(GHEF)
Yves Lecarpentier
Jean-No?l Vallée
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机构:
Centre Hospitalier Universitaire(CHU)Amiens Picardie,Université Picardie Jules Verne(UPJV)Department of Clinical Research and Innovation (DRCI), Foch Hospital
2. Centre de Recherche Clinique,Grand H?pital de l'Est Francilien(GHEF)
机构:
Grand Hop Est Francilien GHEF, Ctr Rech Clin, F-77100 Meaux, Seine & Marne, FranceFoch Hosp, Dept Clin Res & Innovat DRCI, F-92150 Suresnes, France
机构:
Univ Calif San Diego, Ctr Personalized Canc Therapy, UCSD Moores Canc Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Ctr Personalized Canc Therapy, UCSD Moores Canc Ctr, La Jolla, CA 92093 USA
Krishnamurthy, Nithya
Kurzrock, Razelle
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Univ Calif San Diego, Ctr Personalized Canc Therapy, UCSD Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Div Hematol Oncol, La Jolla, CA 92093 USAUniv Calif San Diego, Ctr Personalized Canc Therapy, UCSD Moores Canc Ctr, La Jolla, CA 92093 USA