Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/beta-catenin pathway

被引:14
|
作者
Vallee, Alexandre [1 ]
Lecarpentier, Yves [2 ]
Vallee, Jean-Noel [3 ,4 ]
机构
[1] Foch Hosp, Dept Clin Res & Innovat DRCI, Suresnes, France
[2] Grand Hop Est Francilien GHEF, Ctr Rech Clin, Meaux, Seine & Marne, France
[3] Univ Picardie Jules Verne UPJV, Ctr Hosp Univ CHU Amiens Picardie, Amiens, France
[4] Univ Poitiers, UMR CNRS 7348, Lab Math & Applicat LMA, Poitiers, France
关键词
NF-KAPPA-B; ACTIVATED RECEPTOR-GAMMA; NEUROTROPHIC FACTOR BDNF; SYNTHASE KINASE 3-BETA; BETA-CATENIN; CIRCADIAN CLOCK; ENDOCANNABINOID SYSTEM; PPAR-GAMMA; SIGNALING PATHWAY; OXIDATIVE STRESS;
D O I
10.1038/s41380-021-01086-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear. Recent findings have shown that oxidative stress, inflammation, and glutamatergic pathways play key roles in the causes of OCD. However, first-line therapies include cognitive-behavioral therapy but only 40% of the patients respond to this first-line therapy. Research for new treatment is mandatory. This review focuses on the potential effects of cannabidiol (CBD), as a potential therapeutic strategy, on OCD and some of the presumed mechanisms by which CBD provides its benefit properties. CBD medication downregulates GSK-3 beta, the main inhibitor of the WNT/beta-catenin pathway. The activation of the WNT/beta-catenin could be associated with the control of oxidative stress, inflammation, and glutamatergic pathway and circadian rhythms dysregulation in OCD. Future prospective clinical trials could focus on CBD and its different and multiple interactions in OCD.
引用
收藏
页码:230 / 248
页数:19
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