Overview of incretin hormones

被引：46

作者：

Efendic, S ^{[1
]}

Portwood, N ^{[1
]}

机构：

[1] Karolinska Inst, Dept Mol Med, Endocrine & Diabet Unit, Stockholm, Sweden

来源：

HORMONE AND METABOLIC RESEARCH | 2004年 / 36卷 / 11-12期

关键词：

incretin hormones; insulin glucagon-like peptide-1 (GLP-1); type; 2; diabetes;

D O I：

10.1055/s-2004-826157

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Incretins are hormones released by nutrients from the GI tract. They amplify glucose-induced insulin release. By raising circulating incretin levels, oral glucose provokes a higher insulin response than that resulting from intravenous glucose. The two most important incretin hormones are glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). In patients with type 2 diabetes, the incretin effect is decreased, mainly due to loss of the GIP-regulated second phase of insulin secretion, and because of a decreased secretion of GLP-1. In addition to its insulintropic effect, GLP-1 inhibits glucagon release, prolongs gastric emptying, and leads to decreases in body-weight, all of which explain the marked antidiabetogenic effect of this incretin hormone.

引用

页码：742 / 746

页数：5

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