Characterization of glucose sensor prepared with the electropolymerized pyrrole containing a saccharide unit

Amperometric glucose sensors were prepared by electropolymerization of a pyrrole derivative having a saccharide unit, 1-(3-D-gluconamidopropyl) pyrrole, in the presence of glucose oxidase (GOD). The response current of the GOD-immobilized electrode was approximately stable for 50 days after an initial loss of signal over the first few days. However, the interference of electroactive compounds such as ascorbic acid, uric acid and acetaminophen to the glucose response was large. Such an interference of electroactive compounds was largely Lowered by using the GOD-immobilized electrode with Nafion and PPD films as inner film, but the influence of uric acid still remained. The use of Nafion film as the inner film, was more effective in reducing the interference of electroactive compounds on glucose response than that of poly(o-phenylenediamine),which the use of both film produced the best results in the interference study.