Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer

被引：162

作者：

Zhang, Yunjiao ^{[1
,2
]}

Sha, Rui ^{[3
]}

Zhang, Lan ^{[4
,5
]}

Zhang, Wenbin ^{[1
]}

Jin, Peipei ^{[1
,2
]}

Xu, Weiguo ^{[6
]}

Ding, Jianxun ^{[6
,7
]}

Lin, Jun ^{[3
]}

Qian, Jing ^{[1
,2
]}

Yao, Guangyu ^{[3
]}

Zhang, Rui ^{[1
]}

Luo, Fanchen ^{[3
]}

Zeng, Jie ^{[4
,5
]}

Cao, Jie ^{[1
]}

Wen, Long-ping ^{[1
,2
]}

机构：

[1] South China Univ Technol, Sch Med, Guangzhou Peoples Hosp 1, Dept Colorectal & Anal Surg, Guangzhou 510006, Guangdong, Peoples R China

[2] South China Univ Technol, Inst Life Sci, Nanobio Lab, Guangzhou 510006, Guangdong, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[4] Univ Sci & Technol China, Ctr Adv Nanocatalysis CAN USTC, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China

[5] Univ Sci & Technol China, Dept Chem Phys, Hefei 230026, Anhui, Peoples R China

[6] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China

[7] Southern Med Univ, Nanfang Hosp, Breast Ctr, Guangzhou 510515, Guangdong, Peoples R China

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

CONVERSION EFFICIENCY; THERANOSTIC AGENTS; NANOCRYSTALS; CELLS; NANOCOMPOSITES; CHEMOTHERAPY; COMBINATION; INDUCTION; STABILITY; ABLATION;

D O I：

10.1038/s41467-018-06529-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chemo-PTT, which combines chemotherapy with photothermal therapy, offers a viable approach for the complete tumor eradication but would likely fail in drug-resistant situations if conventional chemotherapeutic agents are used. Here we show that a type of copper (Cu)-palladium (Pd) alloy tetrapod nanoparticles (TNP-1) presents an ideal solution to the chemo-PTT challenges. TNP-1 exhibit superior near-infrared photothermal conversion efficiency, thanks to their special sharp-tip structure, and induce pro-survival autophagy in a shape- and composition-dependent manner. Inhibition of autophagy with 3-methyl adenine or chloroquine has a remarkable synergistic effect on TNP-1-mediated PTT in triple-negative (4T1), drug-resistant (MCF7/MDR) and patient-derived breast cancer models, achieving a level of efficacy unattainable with TNP-2, the identically-shaped CuPd nanoparticles that have a higher photothermal conversion efficiency but no autophagy-inducing activity. Our results provide a proof-of-concept for a chemo-PTT strategy, which utilizes autophagy inhibitors instead of traditional chemotherapeutic agents and is particularly useful for eradicating drugresistant cancer.

引用

页数：13

共 43 条

[11] Cancer drug resistance: an evolving paradigm [J].