Machine Perfusion of Donation After Circulatory Death Liver and Lungs Before Combined Liver-lung Transplantation

被引:6
作者
van Leeuwen, Otto B. [1 ]
Bruggenwirth, Isabel M. A. [1 ]
de Kleine, Ruben H. J. [1 ]
van den Berg, Aad P. [2 ]
Verschuuren, Erik A. M. [3 ]
Erasmus, Michiel E. [4 ]
Porte, Robert J. [1 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Sect Hepatobiliary Surg & Liver Transplantat, Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiothorac Surg, Groningen, Netherlands
关键词
SINGLE-CENTER EXPERIENCE; SCORE;
D O I
10.1097/TXD.0000000000001165
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Shortage of deceased donor organs for transplantation has led to the increased use of organs from donation after circulatory death (DCD) donors. There are currently no reports describing outcomes after multiorgan transplantation with DCD livers. The use of DCD organs for multiorgan transplantation can be enhanced if the detrimental effects of prolonged cold ischemia and subsequent ischemia-reperfusion injury are overcome. We present a case in which the liver and lungs of a DCD donor were preserved using ex situ machine perfusion for combined liver-lung transplantation. The recipient was a 19-year-old male patient requiring bilateral lung transplantation for severe progressive pleural parenchymal fibroelastosis and portal hypertension with portal vein thrombosis. The donor liver was preserved with dual hypothermic oxygenated machine perfusion, whereas the lungs were perfused using ex vivo lung perfusion. With ex vivo lung perfusion, total preservation time of right and left lung reached 17 and 21 h, respectively. Now, 2 y after transplantation, liver function is normal and lung function is improving. To conclude, we suggest that combined transplantation of DCD liver and lungs is feasible when cold ischemia is reduced with ex situ machine perfusion preservation.
引用
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页数:4
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