Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching

被引：12

作者：

Chiba, Naoko ^{[1
,2
]}

Murayama, Somay Y. ^{[3
]}

Morozumi, Miyuki ^{[1
]}

Iwata, Satoshi ^{[1
]}

Ubukata, Kimiko ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Infect Dis, Tokyo, Japan

[2] Gunma Univ, Grad Sch Med, Dept Bacteriol, Gunma, Japan

[3] Nihon Univ, Grad Sch Pharm, Lab Med Microbiol, Chiba, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 09期

关键词：

Streptococcus pneumoniae; capsular switching; gPRSP; serotype; 3; INVASIVE PNEUMOCOCCAL DISEASES; DRUG-RESISTANCE; JAPAN; ADULTS;

D O I：

10.1128/AAC.00478-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n = 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillinsusceptible strain of serotype 3.

引用

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