Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson's Disease Models

被引:22
作者
Cho, Bongki [1 ]
Kim, Taeyun [2 ,3 ]
Huh, Yu-Jin [2 ,3 ]
Lee, Jaemin [2 ]
Lee, Yun-Il [1 ,3 ]
机构
[1] Daegu Gyeongbuk Inst Sci & Technol, Div Biotechnol, Daegu 42988, South Korea
[2] Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea
[3] Daegu Gyeongbuk Inst Sci & Technol, Well Aging Res Ctr, Daegu 42988, South Korea
基金
新加坡国家研究基金会;
关键词
Parkinson's disease (PD); mitochondrial dysfunction; dynamics; hormesis; proteostasis; ubiquitin-proteasome system (UPS); autophagy; mitophagy; natural compounds; ALPHA-SYNUCLEIN AGGREGATION; PROTECTS DOPAMINERGIC-NEURONS; UBIQUITIN-PROTEASOME SYSTEM; NEUROBLASTOMA SH-SY5Y CELLS; MPTP-INDUCED PARKINSONISM; INDUCED OXIDATIVE STRESS; MPP+-INDUCED APOPTOSIS; INDUCED RAT MODEL; SUBSTANTIA-NIGRA; MOUSE MODEL;
D O I
10.3390/ijms20205208
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Parkinson's disease (PD) is a well-known age-related neurodegenerative disorder associated with longer lifespans and rapidly aging populations. The pathophysiological mechanism is a complex progress involving cellular damage such as mitochondrial dysfunction and protein homeostasis. Age-mediated degenerative neurological disorders can reduce the quality of life and also impose economic burdens. Currently, the common treatment is replacement with levodopa to address low dopamine levels; however, this does not halt the progression of PD and is associated with adverse effects, including dyskinesis. In addition, elderly patients can react negatively to treatment with synthetic neuroprotection agents. Recently, natural compounds such as phytochemicals with fewer side effects have been reported as candidate treatments of age-related neurodegenerative diseases. This review focuses on mitochondrial dysfunction, oxidative stress, hormesis, proteostasis, the ubiquitin-proteasome system, and autophagy (mitophagy) to explain the neuroprotective effects of using natural products as a therapeutic strategy. We also summarize the efforts to use natural extracts to develop novel pharmacological candidates for treatment of age-related PD.
引用
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页数:19
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