Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior

被引：35

作者：

Cortese, Bernadette M. ^{[1
]}

Mitchell, Todd R. ^{[2
]}

Galloway, Matthew P. ^{[3
,4
]}

Prevost, Kristen E. ^{[3
]}

Fang, Jidong ^{[5
]}

Moore, Gregory J. ^{[5
,6
]}

Uhde, Thomas W. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA

[2] Univ Illinois, Coll Med Peoria, Dept Emergency Med, Peoria, IL 61637 USA

[3] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA

[4] Wayne State Univ, Sch Med, Dept Anesthesia, Detroit, MI 48201 USA

[5] Penn State Univ, Coll Med, Dept Psychiat, Hershey, PA 17033 USA

[6] Penn State Univ, Coll Med, Dept Radiol, Hershey, PA 17033 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2010年 / 99卷 / 04期

关键词：

Glutamate; Risk taking; Anxiety; Fear; Posttraumatic stress disorder (PTSD); Sleep deprivation; Rats; Elevated plus maze; Cortico-limbic circuit; Medial prefrontal cortex; Hippocampus; Amygdala; Thalamus; High resolution-magic angle spinning proton magnetic resonance spectroscopy (HR-MAS. H-1 MRS); POSTTRAUMATIC-STRESS-DISORDER; MAGNETIC-RESONANCE-SPECTROSCOPY; ELEVATED PLUS-MAZE; MEDIAL PREFRONTAL CORTEX; SLEEP-DEPRIVATION INCREASES; CHILDHOOD SEXUAL-ABUSE; LONG-TERM POTENTIATION; NMDA RECEPTOR FUNCTION; PROTON NMR-SPECTRA; HIPPOCAMPAL VOLUME;

D O I：

10.1016/j.physbeh.2009.12.005

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed. (C) 2009 Published by Elsevier Inc.

引用

页码：445 / 450

页数：6

共 76 条

[1]

ANDREW ER, 1959, NATURE, V1802, P183

[2]

Baldwin David S, 2007, Neuropsychiatr Dis Treat, V3, P185, DOI 10.2147/nedt.2007.3.2.185

[3] Regional dissociations within the hippocampus - memory and anxiety [J].

Bannerman, DM ;

Rawlins, JNP ;

McHugh, SB ;

Deacon, RMJ ;

Yee, BK ;

Bast, T ;

Zhang, WN ;

Pothuizen, HHJ ;

Feldon, J .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2004, 28 (03) :273-283

[4] Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions [J].

Bechara, A ;

Tranel, D ;

Damasio, H .

BRAIN, 2000, 123 :2189-2202

[5] INSENSITIVITY TO FUTURE CONSEQUENCES FOLLOWING DAMAGE TO HUMAN PREFRONTAL CORTEX [J].

BECHARA, A ;

DAMASIO, AR ;

DAMASIO, H ;

ANDERSON, SW .

COGNITION, 1994, 50 (1-3) :7-15

[6] Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: A preliminary report [J].

Berlant, J ;

van Kammen, DP .

JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (01) :15-20

[7] Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonhallucinatory posttraumatic stress disorder [J].

Berlant, Jeffrey L. .

BMC PSYCHIATRY, 2004, 4 (1)

[8] Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze [J].

Bertoglio, Leandro Jose ;

Zangrossi, Helio, Jr. .

BEHAVIOURAL PHARMACOLOGY, 2006, 17 (07) :589-596

[9] Paradoxical sleep deprivation increases the content of glutamate and glutamine in rat cerebral cortex [J].

Bettendorff, L ;

SallanonMoulin, M ;

Touret, M ;

Wins, P ;

Margineanu, I ;

Schoffeniels, E .

SLEEP, 1996, 19 (01) :65-71

[10] Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study [J].

Bremner, JD ;

Mletzko, T ;

Welter, S ;

Quinn, S ;

Williams, C ;

Brummer, M ;

Siddiq, S ;

Reed, L ;

Heim, CM ;

Nemeroff, CB .

JOURNAL OF PSYCHOPHARMACOLOGY, 2005, 19 (02) :159-165

← 1 2 3 4 5 6 7 8 →