The molecular mechanism of nuclear signaling for degradation of cytoplasmic DNA: Importance in DNA damage response and cancer*

被引：3

作者：

Mohammadi, Erfan ^{[1
,2
]}

Sadoughi, Fatemeh ^{[3
]}

Younesi, Simin ^{[4
]}

Karimian, Ansar ^{[1
]}

Asemi, Zatollah ^{[3
]}

Farsad-Akhtar, Nader ^{[2
]}

Jahanbakhshi, Fahime ^{[5
]}

Jamilian, Hamidreza ^{[6
]}

Yousefi, Bahman ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[2] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran

[3] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

[4] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia

[5] Shahid Beheshti Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran

[6] Arak Univ Med Sci, Dept Psychiat, Arak, Iran

来源：

DNA REPAIR | 2021年 / 103卷

关键词：

DNA damage response; DNA repair; Molecular mechanisms; Enzymes; AUTOPHAGY; KINASE; HUR; PHOSPHORYLATION; CHECKPOINTS; PATHWAYS; BINDING; REPAIR; EXPORT; ROLES;

D O I：

10.1016/j.dnarep.2021.103115

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This review summarizes and addresses non-coding RNAs (rRNA, tRNA, Vault and Y RNA, snRNA, and miRNA) cytoplasmic decay pathways, the molecules, enzymes, and modifications such as uridylation, which play vital roles in the degradation processes in various eukaryotic organisms. Plus, SIRT1 ' s role in fundamental cellular processes, including autophagy, DNA repair, DNA damage response (DDR), and the molecular mechanisms, is explored. Further, the HuR (an RNA-binding protein) impact on the expression of genes following DNA damage, and the pathways that regulate HuR function, which is through phosphorylation by Chk1/Cdk1 and Chk2, are specified. Finally, the role of DIF1/ Rnr2-Rnr4 in DDR has been discussed.

引用

页数：8

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