Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

被引：38

作者：

Arunkumar, Nithya ^{[1
,2
,3
]}

Bucher, Dominik B. ^{[1
,3
,4
]}

Turner, Matthew J. ^{[1
,5
]}

Hon, Patrick Tom ^{[6
]}

Glenn, David ^{[1
]}

Lehmkuhl, Soren ^{[6
]}

Lukin, Mikhail D. ^{[1
]}

Park, Hongkun ^{[1
,7
]}

Rosen, Matthew S. ^{[1
,8
,9
]}

Theis, Thomas ^{[6
,10
,11
]}

Walsworth, Ronald L. ^{[1
,2
,3
,5
,12
,13
]}

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Univ Maryland, Quantum Technol Ctr, College Pk, MD 20742 USA

[3] Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA

[4] Tech Univ Munich, Dept Chem, Munich, Germany

[5] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

[6] North Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

[7] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[8] Massachusetts Gen Hosp, AA Martinos Ctr Biomed Imaging, Boston, MA 02129 USA

[9] Harvard Med Sch, Boston, MA 02129 USA

[10] North Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA

[11] UNC & NC State Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[12] Univ Maryland, Dept Phys, College Pk, MD 20742 USA

[13] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA

来源：

PRX QUANTUM | 2021年 / 2卷 / 01期

关键词：

NUCLEAR-MAGNETIC-RESONANCE; N-15; HYPERPOLARIZATION; PARA-HYDROGEN; SABRE; POLARIZATION; SENSITIVITY; FIELD; PARAHYDROGEN; METABOLISM; NAD(+);

D O I：

10.1103/PRXQuantum.2.010305

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Optically probed nitrogen-vacancy (NV)) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 pl. However, a key challenge for NV-NMR spectroscopy is detecting samples at millimolar concentrations. Here we demonstrate an increase in NV-NMR proton concentration sensitivity by hyperpolarizing sample proton spins to about 0.5% through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR spectroscopy of small-molecule sample concentrations as low as 1 mM in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low-concentration molecules and their dynamics in complex micron-scale systems such as single cells.

引用

页数：12

共 37 条

[1] Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer [J].