The Analysis of Cyanide and its Breakdown Products in Biological Samples

被引：90
作者：
Logue, Brian A. [1 ]
Hinkens, Diane M. [1 ]
Baskin, Steven I. [2 ]
Rockwood, Gary A. [2 ]
机构：
[1] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA
[2] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA
来源：
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2010年 / 40卷 / 02期
基金：
美国国家卫生研究院;
关键词：
cyanide; thiocyanate; 2-amino-2-thiazoline-4-carboxylic acid (ATCA); chemical warfare agent; exposure; toxicology; analytical methods; PERFORMANCE LIQUID-CHROMATOGRAPHY; HEADSPACE GAS-CHROMATOGRAPHY; SELECTIVE-MEMBRANE-ELECTRODE; SOLID-PHASE MICROEXTRACTION; METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID; NITROGEN PHOSPHORUS DETECTION; BLOOD CYANIDE; ION CHROMATOGRAPHY; WHOLE-BLOOD; MASS-SPECTROMETRY;
D O I：
10.1080/10408340903535315
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Cyanide is a toxic chemical that may be introduced into living organisms as a result of natural processes and/or anthropogenic uses (legal or illicit). Exposure to cyanide can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, law-enforcement, military, forensic, research, or veterinary purposes. This review will discuss current bioanalytical techniques used for the verification of cyanide exposure, identify common problems associated with the analysis of cyanide and its biological breakdown products, and briefly address the metabolism and toxicokinetics of cyanide and its breakdown products in biological systems.
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页码：122 / 147
页数：26
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