The molecular choreography of a store-operated calcium channel

被引：418

作者：

Lewis, Richard S. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA

来源：

NATURE | 2007年 / 446卷 / 7133期

关键词：

D O I：

10.1038/nature05637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.

引用

页码：284 / 287

页数：4

共 42 条

[1] Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum [J].

Baba, Yoshihiro ;

Hayashit, Kenji ;

Fujii, Yoko ;

Mizushima, Akiko ;

Watarai, Hiroshi ;

Wakamori, Minoru ;

Numaga, Takuro ;

Mori, Yasuo ;

Iino, Masamitsu ;

Hikida, Masaki ;

Kurosaki, Tomohiro .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16704-16709

[2] CIF and other mysteries of the store-operated Ca2+-entry pathway [J].

Bolotina, VM ;

Csutora, P .

TRENDS IN BIOCHEMICAL SCIENCES, 2005, 30 (07) :378-387

[3] Measurements of the free luminal ER Ca2+ concentration with targeted "cameleon" fluorescent proteins [J].

Demaurex, N ;

Frieden, M .

CELL CALCIUM, 2003, 34 (02) :109-119

[4] SIGNALING BETWEEN INTRACELLULAR CA2+ STORES AND DEPLETION-ACTIVATED CA2+ CHANNELS GENERATES [CA2+](I) OSCILLATIONS IN T-LYMPHOCYTES [J].

DOLMETSCH, RE ;

LEWIS, RS .

JOURNAL OF GENERAL PHYSIOLOGY, 1994, 103 (03) :365-388

[5] Gene regulation mediated by calcium signals in T lymphocytes [J].

Feske, S ;

Giltnane, J ;

Dolmetsch, R ;

Staudt, LM ;

Rao, A .

NATURE IMMUNOLOGY, 2001, 2 (04) :316-324

[6] A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function [J].

Feske, S ;

Gwack, Y ;

Prakriya, M ;

Srikanth, S ;

Puppel, SH ;

Tanasa, B ;

Hogan, PG ;

Lewis, RS ;

Daly, M ;

Rao, A .

NATURE, 2006, 441 (7090) :179-185

[7] A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients [J].

Feske, S ;

Prakriya, M ;

Rao, A ;

Lewis, RS .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (05) :651-662

[8] The assembly of calcium release units in cardiac muscle [J].

Franzini-Armstrong, C ;

Protasi, F ;

Tijskens, P .

COMMUNICATIVE CARDIAC CELL, 2005, 1047 :76-85

[9] DEPLETION OF INTRACELLULAR CALCIUM STORES ACTIVATES A CALCIUM CURRENT IN MAST-CELLS [J].

HOTH, M ;

PENNER, R .

NATURE, 1992, 355 (6358) :353-356

[10] STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels [J].

Huang, Guo N. ;

Zeng, Weizhong ;

Kim, Joo Young ;

Yuan, Joseph P. ;

Han, Linhuang ;

Muallem, Shmuel ;

Worley, Paul F. .

NATURE CELL BIOLOGY, 2006, 8 (09) :1003-U96

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