Hyaluronic Acid-Modified Multifunctional Q-Graphene for Targeted Killing of Drug-Resistant Lung Cancer Cells

被引：57

作者：

Luo, Yanan ^{[1
,3
]}

Cai, Xiaoli ^{[1
]}

Li, He ^{[2
]}

Lin, Yuehe ^{[2
,3
]}

Du, Dan ^{[1
,2
,3
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China

[2] Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA

[3] Washington State Univ, Paul G Allen Sch Global Anim Hlth, POB 647090, Pullman, WA 99164 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Q-Graphene; drug delivery; MDR; tumor cell targeting; imaging; MULTIWALLED CARBON NANOTUBES; CONJUGATED GRAPHENE; PHOTODYNAMIC THERAPY; ANTICANCER DRUG; CO-DELIVERY; IN-VITRO; OXIDE; NANOPARTICLES; LIPOSOMES; EFFICACY;

D O I：

10.1021/acsami.5b11471

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Considering the urgent need to explore multifunctional drug delivery system for overcoming multidrug resistance, we prepared a new nanocarbon material Q-Graphene as a nanocarrier for killing drug-resistant lung cancer cells. Attributing to the introduction of hyaluronic acid and rhodamine B isothiocyanate (RBITC), the Q-Graphene-based drug delivery system was endowed with dual function of targeted drug delivery and fluorescence imaging. Additionally, doxorubicin (DOX) as a model drug was loaded on the surface of Q-Graphene via pi-pi stacking. Interestingly, the fluorescence of DOX was quenched by Q-Graphene due to its strong electron-accepting capability, and a significant recovery of fluorescence was observed, while DOX was released from Q-Graphene. Because of the RBITC labeling and the effect of fluorescence quenching/restoring of Q-Graphene, the uptake of nanoparticles and intracellular DOX release can be tracked. Overall, a highly promising multifunctional nanoplatform was developed for tracking and monitoring targeted drug delivery for efficiently killing drug-resistant cancer cells.

引用

页码：4048 / 4055

页数：8

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