Challenges and Recommendations for Placebo Controls in Randomized Trials in Physical and Rehabilitation Medicine A Report of the International Placebo Symposium Working Group

被引：81

作者：

Fregni, Felipe ^{[1
]}

Imamura, Marta ^{[2
]}

Chien, Hsin Fen ^{[2
]}

Lew, Henry L. ^{[1
]}

Boggio, Paulo ^{[3
]}

Kaptchuk, Ted J. ^{[1
]}

Riberto, Marcelo ^{[2
]}

Hsing, Wu Tu ^{[2
]}

Battistella, Linamara Rizzo ^{[2
]}

Furlan, Andrea ^{[4
,5
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA USA

[2] Univ Sao Paulo, Sao Paulo, Brazil

[3] Univ Presbiteriana Mackenzie, Sao Paulo, Brazil

[4] Toronto Rehabil Inst, Toronto, ON, Canada

[5] Univ Toronto, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION | 2010年 / 89卷 / 02期

关键词：

Placebo; Physical and Rehabilitation Medicine; Randomized Clinical Trials; Methodology; Clinical Trials Design; Ethics; Acupuncture; Low-Back Pain; DIRECT-CURRENT STIMULATION; LOW-BACK-PAIN; CLINICAL-TRIALS; DOUBLE-BLIND; PATIENT COMMUNICATION; ACUPUNCTURE; ETHICS; METAANALYSIS; EFFICACY; EXPECTATIONS;

D O I：

10.1097/PHM.0b013e3181bc0bbd

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Compared with other specialties, the field of physical and rehabilitation medicine has not received the deserved recognition from clinicians and researchers in the scientific community. One of the reasons is the lack of sound evidence to support the traditional physical and rehabilitation medicine treatments. The best way to change this disadvantage is through a well conducted clinical research, such as standard placebo- or sham-controlled randomized clinical trials. Therefore, having placebo groups in clinical trials is essential to improve the level of evidence-based practice in physical and rehabilitation medicine that ultimately translates to better clinical care. To address the challenges for the use of placebo in physical and rehabilitation medicine and randomized clinical trials and to create useful recommendations, we convened a working group during the inaugural International Symposium in Placebo (February 2009, in Sao Paulo, Brazil) in which the following topics were discussed: (1) current status of randomized clinical trials in physical and rehabilitation medicine, (2) challenges for the use of placebo in physical and rehabilitation medicine, (3) bioethics, (4) use of placebo in acupuncture trials and for the treatment of low-back pain, (5) mechanisms of placebo, and (6) insights from other specialties. The current article represents the consensus report from the working group.

引用

页码：160 / 172

页数：13