Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study

被引:12
作者
Robinson, Helen [1 ]
Barrett, Helen [2 ]
Gomez-Arango, Luisa [3 ]
McIntyre, H. David [2 ]
Callaway, Leonie [4 ]
Nitert, Marloes Dekker [3 ]
机构
[1] Royal Brisbane & Womens Hosp, Dept Obstetr Med, Butterfield St, Herston, Qld 4029, Australia
[2] Univ Queensland, Mater Res Inst, Brisbane, Qld 4101, Australia
[3] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia
[4] Royal Brisbane & Womens Hosp, Womens & Newborn Serv, Butterfield St, Herston, Qld 4029, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
microbiome; pregnancy; obesity; ketonuria; Roseburia; BUTYRATE-PRODUCING BACTERIA; METABOLISM; PREGNANCY; METAGENOME; HORMONES;
D O I
10.3390/nu11081836
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The gut microbiome in pregnancy has been associated with various maternal metabolic and hormonal markers involved in glucose metabolism. Maternal ketones are of particular interest due to the rise in popularity of low-carbohydrate diets. We assessed for differences in the composition of the gut microbiota in pregnant women with and without ketonuria at 16 weeks gestation. Fecal samples were obtained from 11 women with fasting ketonuria and 11 matched controls. The samples were analyzed to assess for differences in gut microbiota composition by 16S rRNA sequencing. Supervised hierarchical clustering analysis showed significantly different beta-diversity between women with and without ketonuria, but no difference in the alpha-diversity. Group comparisons and network analysis showed that ketonuria was associated with an increased abundance of the butyrate-producing genus Roseburia. The bacteria that contributed the most to the differences in the composition of the gut microbiota included Roseburia, Methanobrevibacter, Uncl. RF39, and Dialister in women with ketonuria and Eggerthella, Phascolarctobacterium, Butyricimonas, and Uncl. Coriobacteriaceae in women without ketonuria. This study found that the genus Roseburia is more abundant in the gut microbiota of pregnant women with ketonuria. Roseburia is a butyrate producing bacterium and may increase serum ketone levels.
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页数:10
相关论文
共 28 条
[1]   Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [J].
Bajer, Lukas ;
Kverka, Miloslav ;
Kostovcik, Martin ;
Macinga, Peter ;
Dvorak, Jiri ;
Stehlikova, Zuzana ;
Brezina, Jan ;
Wohl, Pavel ;
Spicak, Julius ;
Drastich, Pavel .
WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (25) :4548-4558
[2]   Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls [J].
Chen, Jun ;
Chia, Nicholas ;
Kalari, Krishna R. ;
Yao, Janet Z. ;
Novotna, Martina ;
Soldan, M. Mateo Paz ;
Luckey, David H. ;
Marietta, Eric V. ;
Jeraldo, Patricio R. ;
Chen, Xianfeng ;
Weinshenker, Brian G. ;
Rodriguez, Moses ;
Kantarci, Orhun H. ;
Nelson, Heidi ;
Murray, Joseph A. ;
Mangalam, Ashutosh K. .
SCIENTIFIC REPORTS, 2016, 6
[3]  
CHURCHILL J A, 1969, Pan American Health Organization Scientific Publication, V185, P30
[4]   Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and α-linolenate [J].
Cunnane, SC ;
Menard, CR ;
Likhodii, SS ;
Brenna, JT ;
Crawford, MA .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1999, 60 (5-6) :387-392
[5]   Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces [J].
Duncan, Sylvia H. ;
Belenguer, Alvaro ;
Holtrop, Grietje ;
Johnstone, Alexandra M. ;
Flint, Harry J. ;
Lobley, Gerald E. .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (04) :1073-1078
[6]   Understanding the Physiology of FGF21 [J].
Fisher, Ffolliott Martin ;
Maratos-Flier, Eleftheria .
ANNUAL REVIEW OF PHYSIOLOGY, VOL 78, 2016, 78 :223-241
[7]   Connections Between the Gut Microbiome and Metabolic Hormones in Early Pregnancy in Overweight and Obese Women [J].
Gomez-Arango, Luisa F. ;
Barrett, Helen L. ;
McIntyre, H. David ;
Callaway, Leonie K. ;
Morrison, Mark ;
Nitert, Marloes Dekker .
DIABETES, 2016, 65 (08) :2214-2223
[8]  
Hamdi Kobra, 2006, Arch Iran Med, V9, P144
[9]   Lipid metabolism in pregnancy and its consequences in the fetus and newborn [J].
Herrera, E .
ENDOCRINE, 2002, 19 (01) :43-55
[10]   Gut metagenome in European women with normal, impaired and diabetic glucose control [J].
Karlsson, Fredrik H. ;
Tremaroli, Valentina ;
Nookaew, Intawat ;
Bergstrom, Goran ;
Behre, Carl Johan ;
Fagerberg, Bjorn ;
Nielsen, Jens ;
Backhed, Fredrik .
NATURE, 2013, 498 (7452) :99-+