Augmentation of Radiation-Induced Apoptosis by Ellagic Acid

被引：13

作者：

Bhosle, Sushma Madhukar ^{[1
]}

Ahire, Vidhula R. ^{[1
]}

Henry, Monica S. ^{[1
]}

Thakur, Vikas S. ^{[1
]}

Huilgol, Nagraj G. ^{[2
]}

Mishra, Kaushala Prasad ^{[1
,3
]}

机构：

[1] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India

[2] Dr Balabhai Nanavati Hosp, Div Radiat Oncol, Bombay, Maharashtra, India

[3] United Res Ctr, Allahabad, Uttar Pradesh, India

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 03期

关键词：

Cervical cancer; Oxidative damage; Apoptosis; Radiation; Ellagic acid; NF-KAPPA-B; OXIDATIVE STRESS; CERVICAL-CARCINOMA; CYTOCHROME-C; CANCER CELLS; IN-VITRO; ACTIVATION; BCL-2; QUERCETIN; ARREST;

D O I：

10.3109/07357900902849616

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study evaluates the potential of ellagic acid (EA) as an enhancer of radiation-induced apoptosis in cancer cells. He La cells treated with EA and gamma radiation showed increased superoxide generation, upregulated p53 protein expression, and decreased antioxidant enzymes. We also found that EA and radiation enhance capase-3 activity via oxidative stress, increased intracellular calcium levels, and phospholipase C and cause a drop in mitochondria! potential. These results might provide a basis for prominent reduction of cancer cell using EA as an adjunct to radiotherapy and an opportunity to lower the toxic radiation doses to improve the quality of life.

引用

页码：323 / 330

页数：8

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