CXCL12 and CXCR4 polymorphisms and expressions in peripheral blood from patients of hepatocellular carcinoma

被引：17
作者：
Qin, Li-Feng [1 ,2 ]
Qin, Jin-Mei [1 ]
Zhang, Ji-Qiao [2 ]
Lv, Xiao-Ping [1 ]
Huang, Li-Yi [3 ]
Wang, Jing-Jing [2 ]
机构：
[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Infect Dis, Nanning 530021, Peoples R China
[2] Hubei Univ Nationalities, Affiliated Minda Hosp, Dept Gastroenterol, Enshi 445000, Peoples R China
[3] Guangxi Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanning 530021, Peoples R China
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 13期
关键词：
CXCL12; CXCR4; hepatocellular carcinoma; single nucleotide polymorphism; CANCER STATISTICS; SDF-1; CHEMOKINE; HEPATITIS-B; FACTOR-I; RECEPTOR; CELLS; AIDS; SUSCEPTIBILITY; ASSOCIATION; CHINA;
D O I：
10.2217/fon-2017-0613
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To determine if CXCL12 (rs1801157) and CXCR4 (rs2228014) polymorphisms are associated with hepatocellular carcinoma (HCC) susceptibility, and detect their expressions in peripheral blood. Methods: 206 HCC patients, 252 chronic hepatitis B patients, 221 liver cirrhosis patients and 275 healthy volunteers were recruited. Genes CXCL12 and CXCR4 were amplified and genotyped. Their expression in peripheral blood were detected. Results:CXCL12 rs1801157 and CXCR4 rs2228014 polymorphisms were associated with increased susceptibility of HCC, and genotypes GA/AA and CT/TT may be risk factors of HCC (all p<0.05). Expressions of CXCL12 and CXCR4 in peripheral blood from HCC patients increased significantly (p<0.05). Conclusion: CXCL12 and CXCR4 polymorphisms may be risk factors for HCC, and they may be potential HCC markers. [GRAPHICS] .
引用
收藏
页码：1261 / 1271
页数：11
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