CXCL12 and CXCR4 polymorphisms and expressions in peripheral blood from patients of hepatocellular carcinoma

被引：17

作者：

Qin, Li-Feng ^{[1
,2
]}

Qin, Jin-Mei ^{[1
]}

Zhang, Ji-Qiao ^{[2
]}

Lv, Xiao-Ping ^{[1
]}

Huang, Li-Yi ^{[3
]}

Wang, Jing-Jing ^{[2
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Infect Dis, Nanning 530021, Peoples R China

[2] Hubei Univ Nationalities, Affiliated Minda Hosp, Dept Gastroenterol, Enshi 445000, Peoples R China

[3] Guangxi Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanning 530021, Peoples R China

来源：

FUTURE ONCOLOGY | 2018年 / 14卷 / 13期

关键词：

CXCL12; CXCR4; hepatocellular carcinoma; single nucleotide polymorphism; CANCER STATISTICS; SDF-1; CHEMOKINE; HEPATITIS-B; FACTOR-I; RECEPTOR; CELLS; AIDS; SUSCEPTIBILITY; ASSOCIATION; CHINA;

D O I：

10.2217/fon-2017-0613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To determine if CXCL12 (rs1801157) and CXCR4 (rs2228014) polymorphisms are associated with hepatocellular carcinoma (HCC) susceptibility, and detect their expressions in peripheral blood. Methods: 206 HCC patients, 252 chronic hepatitis B patients, 221 liver cirrhosis patients and 275 healthy volunteers were recruited. Genes CXCL12 and CXCR4 were amplified and genotyped. Their expression in peripheral blood were detected. Results:CXCL12 rs1801157 and CXCR4 rs2228014 polymorphisms were associated with increased susceptibility of HCC, and genotypes GA/AA and CT/TT may be risk factors of HCC (all p<0.05). Expressions of CXCL12 and CXCR4 in peripheral blood from HCC patients increased significantly (p<0.05). Conclusion: CXCL12 and CXCR4 polymorphisms may be risk factors for HCC, and they may be potential HCC markers. [GRAPHICS] .

引用

页码：1261 / 1271

页数：11

共 36 条

[1] [Anonymous], CHIN J CANC PREV TRE
[2] The role of cytokines in hepatocellular carcinoma
Budhu, Anuradha
Wang, Xin Wei
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (06) : 1197 - 1213
[3] Association of CXCL12 and CXCR4 gene polymorphisms with the susceptibility and prognosis of renal cell carcinoma
Cai, C.
Wang, L. -H.
Dong, Q.
Wu, Z. -J.
Li, M. -Y.
Sun, Y. -H.
[J]. TISSUE ANTIGENS, 2013, 82 (03): : 165 - 170
[4] Cancer Statistics in China, 2015
Chen, Wanqing
Zheng, Rongshou
Baade, Peter D.
Zhang, Siwei
Zeng, Hongmei
Bray, Freddie
Jemal, Ahmedin
Yu, Xue Qin
He, Jie
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) : 115 - 132
[5] CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients
de Oliveira, Karen Brajao
Guembarovski, Roberta Losi
Maeda Oda, Julie Massayo
Mantovani, Mario Sergio
Carrera, Clisia Mara
Vissoci Reiche, Edna Maria
Voltarelli, Julio Cesar
da Silva do Amaral Herrera, Ana Cristina
Ehara Watanabe, Maria Angelica
[J]. CYTOKINE, 2011, 55 (02) : 260 - 265
[6] Hepatocellular carcinoma
Forner, Alejandro
Llovet, Josep M.
Bruix, Jordi
[J]. LANCET, 2012, 379 (9822) : 1245 - 1255
[7] Current Strategy for Staging and Treatment: The BCLC Update and Future Prospects
Forner, Alejandro
Reig, Maria E.
Rodriguez de Lope, Carlos
Bruix, Jordi
[J]. SEMINARS IN LIVER DISEASE, 2010, 30 (01) : 61 - 74
[8] Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies
Frick, Vilma Oliveira
Rubie, Claudia
Ghadjar, Pirus
Faust, Sabrina K.
Wagner, Mathias
Graeber, Stefan
Schilling, Martin K.
[J]. TUMOR BIOLOGY, 2011, 32 (01) : 189 - 196
[9] Evidence-based clinical practice guidelines for liver cirrhosis 2015
Fukui, Hiroshi
Saito, Hidetsugu
Ueno, Yoshiyuki
Uto, Hirofumi
Obara, Katsutoshi
Sakaida, Isao
Shibuya, Akitaka
Seike, Masataka
Nagoshi, Sumiko
Segawa, Makoto
Tsubouchi, Hirohito
Moriwaki, Hisataka
Kato, Akinobu
Hashimoto, Etsuko
Michitaka, Kojiro
Murawaki, Toshikazu
Sugano, Kentaro
Watanabe, Mamoru
Shimosegawa, Tooru
[J]. JOURNAL OF GASTROENTEROLOGY, 2016, 51 (07) : 629 - 650
[10] Hou JL, 2017, J CLIN TRANSL HEPATO, V5, P297, DOI 10.14218/JCTH.2016.00019

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