Genetic and Environmental Influences on Regional Brain Uptake of 18F-FDG: A PET Study on Monozygotic and Dizygotic Twins

被引：3
作者：
Watanabe, Shinichiro [1 ]
Kato, Hiroki [1 ]
Shimosegawa, Eku [1 ,2 ]
Hatazawa, Jun [1 ,3 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Nucl Med & Tracer Kinet, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Dept Mol Imaging Med, Suita, Osaka 5650871, Japan
[3] Osaka Univ, Grad Sch Med, Ctr Twin Res, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF NUCLEAR MEDICINE | 2016年 / 57卷 / 03期
关键词：
F-18-FDG PET; cerebral glucose metabolism; twin research; genetic factor; heritability; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; RESONANCE-IMAGING TWIN; CORTICAL SURFACE-AREA; DISEASE; FDG; INJECTION; NETWORK; IMAGES; MICE;
D O I：
10.2967/jnumed.115.164004
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Genetic or environmental influences on cerebral glucose metabolism are unknown. We attempted to reveal these influences in elderly twins by means of F-18-FDG PET. Methods: F-18-FDG uptake was studied in 40 monozygotic and 18 dizygotic volunteer twin pairs aged 30 y or over. We also created 18 control pairs by pairing age and sex-matched genetically unrelated subjects from dizygotic and monozygotic pairs. SUV images of the brain were reconstructed and analyzed by voxel-based statistical analysis with automated region-of-interest setting. The F-18-FDG uptake in each cerebral lobe was semiquantified by taking a ratio of SUVmean in each region of interest to whole-brain SUVaverage. We calculated an intraclass correlation coefficient of SUV ratio in each region of interest for mono zygotic and dizygotic pairs. By comparing differences in coefficients between monozygotic and dizygotic pairs, genetic and environmental contributions were estimated. Results: The intraclass correlation coefficient in monozygotic pairs was significantly higher than that in dizygotic pairs in the parietal lobes bilaterally (P < 0.001) and in the left temporal lobe (P < 0.05) but was not significantly different in other lobes. Conclusion: The present study indicated that in the right and left parietal lobes and left temporal lobe, cerebral glucose metabolism is influenced more by genetics than by environment, whereas in other brain regions the influence of environment is dominant.
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页码：392 / 397
页数：6
相关论文
共 42 条
[1]   Topography of brain glucose hypometabolism and epileptic network in glucose transporter 1 deficiency [J].
Akman, Cigdem Man ;
Provenzano, Frank ;
Wang, Dong ;
Engelstad, Kristin ;
Hinton, Veronica ;
Yu, Julia ;
Tikofsky, Ronald ;
Lchese, Masonari ;
De Vivo, Darryl C. .
EPILEPSY RESEARCH, 2015, 110 :206-215
[2]   Genetic and Environmental Influences on Neuroimaging Phenotypes: A Meta-Analytical Perspective on Twin Imaging Studies [J].
Blokland, Gabriella A. M. ;
de Zubicaray, Greig I. ;
McMahon, Katie L. ;
Wright, Margaret J. .
TWIN RESEARCH AND HUMAN GENETICS, 2012, 15 (03) :351-371
[3]   Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1α-Mediated Target Gene Activation [J].
Brix, Britta ;
Mesters, Jeroen R. ;
Pellerin, Luc ;
Joehren, Olaf .
JOURNAL OF NEUROSCIENCE, 2012, 32 (28) :9727-9735
[4]   POSITRON EMISSION TOMOGRAPHY STUDY OF HUMAN-BRAIN FUNCTIONAL-DEVELOPMENT [J].
CHUGANI, HT ;
PHELPS, ME ;
MAZZIOTTA, JC .
ANNALS OF NEUROLOGY, 1987, 22 (04) :487-497
[5]   MATURATIONAL CHANGES IN CEREBRAL FUNCTION IN INFANTS DETERMINED BY F-18 DG POSITRON EMISSION TOMOGRAPHY [J].
CHUGANI, HT ;
PHELPS, ME .
SCIENCE, 1986, 231 (4740) :840-843
[6]   Metabolic Brain Covariant Networks as Revealed by FDG-PET with Reference to Resting-State fMRI Networks [J].
Di, Xin ;
Biswal, Bharat B. .
BRAIN CONNECTIVITY, 2012, 2 (05) :275-283
[7]   Differential effects of global and cerebellar normalization on detection and differentiation of dementia in FDG-PET studies [J].
Dukart, Juergen ;
Mueller, Karsten ;
Horstmann, Annette ;
Vogt, Barbara ;
Frisch, Stefan ;
Barthel, Henryk ;
Becker, Georg ;
Moeller, Harald E. ;
Villringer, Arno ;
Sabri, Osama ;
Schroeter, Matthias L. .
NEUROIMAGE, 2010, 49 (02) :1490-1495
[8]   Epigenetics in human disease and prospects for epigenetic therapy [J].
Egger, G ;
Liang, GN ;
Aparicio, A ;
Jones, PA .
NATURE, 2004, 429 (6990) :457-463
[9]   A Comparison of Heritability Maps of Cortical Surface Area and Thickness and the Influence of Adjustment for Whole Brain Measures: A Magnetic Resonance Imaging Twin Study [J].
Eyler, Lisa T. ;
Chen, Chi-Hua ;
Panizzon, Matthew S. ;
Fennema-Notestine, Christine ;
Neale, Michael C. ;
Jak, Amy ;
Jernigan, Terry L. ;
Fischl, Bruce ;
Franz, Carol E. ;
Lyons, Michael J. ;
Grant, Michael ;
Prom-Wormley, Elizabeth ;
Seidman, Larry J. ;
Tsuang, Ming T. ;
Fiecas, Mark Joseph A. ;
Dale, Anders M. ;
Kremen, William S. .
TWIN RESEARCH AND HUMAN GENETICS, 2012, 15 (03) :304-314
[10]   Genetic and Environmental Contributions to Regional Cortical Surface Area in Humans: A Magnetic Resonance Imaging Twin Study [J].
Eyler, Lisa T. ;
Prom-Wormley, Elizabeth ;
Panizzon, Matthew S. ;
Kaup, Allison R. ;
Fennema-Notestine, Christine ;
Neale, Michael C. ;
Jernigan, Terry L. ;
Fischl, Bruce ;
Franz, Carol E. ;
Lyons, Michael J. ;
Grant, Michael ;
Stevens, Allison ;
Pacheco, Jennifer ;
Perry, Michele E. ;
Schmitt, J. Eric ;
Seidman, Larry J. ;
Thermenos, Heidi W. ;
Tsuang, Ming T. ;
Chen, Chi-Hua ;
Thompson, Wesley K. ;
Jak, Amy ;
Dale, Anders M. ;
Kremen, William S. .
CEREBRAL CORTEX, 2011, 21 (10) :2313-2321
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