Projection neurons in Drosophila antennal lobes signal the acceleration of odor concentrations

被引:34
|
作者
Kim, Anmo J. [1 ]
Lazar, Aurel A. [1 ]
Slutskiy, Yevgeniy B. [1 ]
机构
[1] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA
来源
ELIFE | 2015年 / 4卷
基金
美国国家卫生研究院;
关键词
SYSTEM-IDENTIFICATION; SENSORY NEURONS; DYNAMICS; MECHANISMS; BEHAVIOR; MELANOGASTER; CHEMOTAXIS; RESPONSES; TRACKING; CIRCUIT;
D O I
10.7554/eLife.06651
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Temporal experience of odor gradients is important in spatial orientation of animals. The fruit fly Drosophila melanogaster exhibits robust odor-guided behaviors in an odor gradient field. In order to investigate how early olfactory circuits process temporal variation of olfactory stimuli, we subjected flies to precisely defined odor concentration waveforms and examined spike patterns of olfactory sensory neurons (OSNs) and projection neurons (PNs). We found a significant temporal transformation between OSN and PN spike patterns, manifested by the PN output strongly signaling the OSN spike rate and its rate of change. A simple two-dimensional model admitting the OSN spike rate and its rate of change as inputs closely predicted the PN output. When cascaded with the rate-of-change encoding by OSNs, PNs primarily signal the acceleration and the rate of change of dynamic odor stimuli to higher brain centers, thereby enabling animals to reliably respond to the onsets of odor concentrations.
引用
收藏
页数:11
相关论文
共 35 条
  • [21] The role of mitochondria in shaping odor responses in Drosophila melanogaster olfactory sensory neurons
    Lucke, Jan
    Kaltofen, Sabine
    Hansson, Bill S.
    Wicher, Dieter
    CELL CALCIUM, 2020, 87
  • [22] Octopaminergic neurons have multiple targets in Drosophila larval mushroom body calyx and can modulate behavioral odor discrimination
    Wong, J. Y. Hilary
    Wan, Bo Angela
    Bland, Tom
    Montagnese, Marcella
    McLachlan, Alex D.
    O'Kane, Cahir J.
    Zhang, Shuo Wei
    Masuda-Nakagawa, Liria M.
    LEARNING & MEMORY, 2021, 28 (02) : 53 - 71
  • [23] Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons
    Xie, Qijing
    Brbic, Maria
    Horns, Felix
    Kolluru, Sai Saroja
    Jones, Robert C.
    Li, Jiefu
    Reddy, Anay R.
    Xie, Anthony
    Kohani, Sayeh
    Li, Zhuoran
    McLaughlin, Colleen N.
    Li, Tongchao
    Xu, Chuanyun
    Vacek, David
    Luginbuhl, David J.
    Leskovec, Jure
    Quake, Stephen R.
    Luo, Liqun
    Li, Hongjie
    ELIFE, 2021, 10
  • [24] Take time: odor coding capacity across sensory neurons increases over time in Drosophila
    Muench, Daniel
    Galizia, C. Giovanni
    JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2017, 203 (12): : 959 - 972
  • [25] Principal component analysis of odor coding at the level of third-order olfactory neurons in Drosophila
    Hiroi, Makoto
    Ohkura, Masamichi
    Nakai, Junichi
    Masuda, Naoki
    Hashimoto, Koichi
    Inoue, Kiichi
    Fiala, Andre
    Tabata, Tetsuya
    GENES TO CELLS, 2013, 18 (12) : 1070 - 1081
  • [26] Calcium imaging revealed no modulatory effect on odor-evoked responses of the Drosophila antennal lobe by two populations of inhibitory local interneurons
    Strube-Bloss, Martin F.
    Grabe, Veit
    Hansson, Bill S.
    Sachse, Silke
    SCIENTIFIC REPORTS, 2017, 7
  • [27] Carbon Dioxide and Fruit Odor Transduction in Drosophila Olfactory Neurons. What Controls their Dynamic Properties?
    French, Andrew S.
    Meisner, Shannon
    Su, Chih-Ying
    Torkkeli, Paeivi H.
    PLOS ONE, 2014, 9 (01):
  • [28] Four Individually Identified Paired Dopamine Neurons Signal Reward in Larval Drosophila
    Rohwedder, Astrid
    Wenz, Nana L.
    Stehle, Bernhard
    Huser, Annina
    Yamagata, Nobuhiro
    Zlatic, Marta
    Truman, James W.
    Tanimoto, Hiromu
    Saumweber, Timo
    Gerber, Bertram
    Thum, Andreas S.
    CURRENT BIOLOGY, 2016, 26 (05) : 661 - 669
  • [29] Feeding-induced changes in allatostatin-A and short neuropeptide F in the antennal lobes affect odor-mediated host seeking in the yellow fever mosquito, Aedes aegypti
    Christ, Peter
    Reifenrath, Anna
    Kahnt, Joerg
    Hauser, Frank
    Hill, Sharon Rose
    Schachtner, Joachim
    Ignell, Rickard
    PLOS ONE, 2017, 12 (11):
  • [30] Presynaptic Ca2+ stores contribute to odor-induced responses in Drosophila olfactory receptor neurons
    Murmu, Meena Sriti
    Stinnakre, Jacques
    Martin, Jean-Rene
    JOURNAL OF EXPERIMENTAL BIOLOGY, 2010, 213 (24) : 4163 - 4173