The Complex Ultrastructure of the Endolysosomal System

被引：259
作者：
Klumperman, Judith [1 ]
Raposo, Graca [2 ,3 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands
[2] Ctr Rech, Inst Curie, F-75248 Paris, France
[3] Struct & Membrane Compartments CNRS UMR144, F-75248 Paris, France
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2014年 / 6卷 / 10期
基金：
美国国家卫生研究院;
关键词：
LYSOSOMAL MEMBRANE-PROTEINS; MHC CLASS-II; LIGHT-ELECTRON MICROSCOPY; TRANS-GOLGI NETWORK; RECEPTOR-MEDIATED ENDOCYTOSIS; CLATHRIN-COATED VESICLES; AP-3 ADAPTER COMPLEX; PLASMA-MEMBRANE; MULTIVESICULAR ENDOSOMES; CORRELATIVE LIGHT;
D O I：
10.1101/cshperspect.a016857
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic network of interacting compartments. Distinct types of endosomes are discerned by kinetic, molecular, and morphological criteria. Although none of these criteria, or combinations thereof, can capture the full complexity of the endolysosomal system, they are extremely useful for experimental purposes. Some membrane domain specializations and specific morphological characteristics can only be seen by ultrastructural analysis after preparation for electron microscopy (EM). Immuno-EM allows a further discrimination of seemingly identical compartments by their molecular makeup. In this review we provide an overview of the ultrastructural characteristics and membrane organization of endosomal compartments, along with their organizing machineries.
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页数：22
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