Reduced adhesion of PBMNCs to endothelium in methylprednisolone-treated MS patients: preliminary results

被引：0

作者：

Gelati, M ^{[1
]}

Corsini, E ^{[1
]}

Dufour, A ^{[1
]}

Ciusani, E ^{[1
]}

Massa, G ^{[1
]}

Frigerio, S ^{[1
]}

Milanese, C ^{[1
]}

Nespolo, A ^{[1
]}

Salmaggi, A ^{[1
]}

机构：

[1] IST NAZL NEUROL C BESTA,I-20133 MILAN,ITALY

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1997年 / 96卷 / 05期

关键词：

methylprednisolone; adhesion phenomena; multiple sclerosis; sVCAM-1; sICAM-1;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Methylprednisolone (MP) is a synthetic steroid commonly used in the treatment of multiple sclerosis (MS) relapses. It has a wide spectrum of activities on immune cells: it might also act by preventing mononuclear cell/endothelium adhesion. We studied adhesion phenomena between cultured human umbilical vein endothelial cells (HUVECs) and PBMNCs (CD45(+), CD14(+)) from 6 MS patients treated in vivo with MP. We also studied fluctuations in CD11a and CD18 levels on lymphocytes and monocytes, as well as changes in serum sICAM-1 and sVCAM-1 concentrations. After MP treatment, PBMNCs adhesion to endothelium decreased at 3 h, while it went back to baseline levels at 24 h. A tendency to increase in both CD11a and CD18 on the surface of lymphocytes was detected, while an increase in serum sVCAM-1 was seen at 3 h.

引用

页码：283 / 292

页数：10

共 27 条

[1] Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone [J].