Review of Mesenchymal Stem Cells and Tumors: Executioner or Coconspirator?

被引:59
作者
Feng, Bing [1 ,2 ]
Chen, Longbang [1 ]
机构
[1] Jinling Hosp, Dept Med Oncol, Nanjing 210002, Peoples R China
[2] Nanjing Univ, Sch Med, Clin Coll, Nanjing 210008, Peoples R China
关键词
mesenchymal stem cells (MSCs); tumor targeted therapy; tumor microenvironment; MARROW STROMAL CELLS; CANCER GENE-THERAPY; BONE-MARROW; IN-VITRO; TARGETED DELIVERY; INTERFERON-BETA; BREAST-CANCER; TRANSFORMATION; EXPRESSION; MSCS;
D O I
10.1089/cbr.2009.0652
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Mesenchymal stem cells (MSCs) are a versatile group of nonhematopoietic stem cells with high potency of proliferation and pluripotency of differentiation. Endogenous MSCs circulate in the blood until being called to sites of inflammation or tumors, where they could differentiate into bone, cartilage, fat, or muscle cells to repair or replace damaged tissue. Ectogenous MSCs also demonstrate satisfactory tropism toward primary tumor sites and metastatic foci with low immunogenicity and thus can be exploited as a cell-mediated gene therapy to counteract tumor growth and development. However, tumor-promoting, and even carcinogenetic, effects of MSCs are also observed both in vitro and in vivo, raising potential risks in clinical applications. Recent advances of MSCs in tumor-targeted biotherapy were summarized. New findings of the interaction between MSCs and tumor cells in the tumor microenvironment were expounded.
引用
收藏
页码:717 / 721
页数:5
相关论文
共 43 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]  
Angoulvant D, 2004, BIORHEOLOGY, V41, P469
[3]   Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines [J].
Birnbaum, Tobias ;
Roider, Julia ;
Schankin, Christoph J. ;
Padovan, Claudio S. ;
Schichor, Christian ;
Goldbrunner, Roland ;
Straube, Andreas .
JOURNAL OF NEURO-ONCOLOGY, 2007, 83 (03) :241-247
[4]   Prophylaxis against carcinogenesis in three kinds of unestablished tumor models via IL12-gene-engineered MSCs [J].
Chen, Xian-cheng ;
Wang, Rui ;
Zhao, Xia ;
Wei, Yu-quan ;
Hu, Min ;
Wang, Yang-sheng ;
Zhang, Xiao-wei ;
Zhang, Ru ;
Zhang, Lin ;
Yao, Bin ;
Wang, Lian ;
Jia, Yong-qian ;
Zeng, Ting-ting ;
Yang, Jin-liang ;
Kan, Bing ;
Lin, Xiao-juan ;
Lei, Song ;
Deng, Hong-xin ;
Wen, Yan-jun ;
Mao, Yong-qiu ;
Li, Jiong .
CARCINOGENESIS, 2006, 27 (12) :2434-2441
[5]   A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs [J].
Chen, Xiancheng ;
Lin, Xiaojuan ;
Zhao, Jianlei ;
Shi, Wei ;
Zhang, Heng ;
Wang, Yongsheng ;
Kan, Bing ;
Du, Licheng ;
Wang, Baiding ;
Wei, Yuquan ;
Liu, Yi ;
Zhao, Xia .
MOLECULAR THERAPY, 2008, 16 (04) :749-756
[6]   Human mesenchymal stem cells modulate B-cell functions [J].
Corcione, A ;
Benvenuto, F ;
Ferretti, E ;
Giunti, D ;
Cappiello, V ;
Cazzanti, F ;
Risso, M ;
Gualandi, F ;
Mancardi, GL ;
Pistoia, V ;
Uccelli, A .
BLOOD, 2006, 107 (01) :367-372
[7]   Mesenchymal Stem Cells in Early Entry of Breast Cancer into Bone Marrow [J].
Corcoran, Kelly E. ;
Trzaska, Katarzyna A. ;
Fernandes, Helen ;
Bryan, Margarette ;
Taborga, Marcelo ;
Srinivas, Venkatesh ;
Packman, Kathryn ;
Patel, Prem S. ;
Rameshwar, Pranela .
PLOS ONE, 2008, 3 (06)
[8]   Inflammation and cancer [J].
Coussens, LM ;
Werb, Z .
NATURE, 2002, 420 (6917) :860-867
[9]   Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals [J].
Djouad, F ;
Plence, P ;
Bony, C ;
Tropel, P ;
Apparailly, F ;
Sany, J ;
Noël, D ;
Jorgensen, C .
BLOOD, 2003, 102 (10) :3837-3844
[10]   Earlier onset of syngeneic tumors in the presence of mesenchymal stem cells [J].
Djouad, Farida ;
Bony, Claire ;
Apparailly, Florence ;
Louis-Plence, Pascale ;
Jorgensen, Christian ;
Noel, Daniele .
TRANSPLANTATION, 2006, 82 (08) :1060-1066