Transgenerational genomic instability in children of irradiated parents as a result of the Chernobyl Nuclear Accident

被引：24

作者：

Aghajanyan, Anna ^{[1
]}

Suskov, Igor ^{[2
]}

机构：

[1] FSI Russian Sci Ctr Roentgenol & Radiol, Cytogenet Lab, Moscow 117997, Russia

[2] Russian Acad Sci, Lab Ecol Genet, NI Vavilov Gen Genet Res Inst, Moscow 119991, Russia

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2009年 / 671卷 / 1-2期

基金：

俄罗斯基础研究基金会;

关键词：

Genomic instability; Children; Parents; Low doses; IONIZING-RADIATION; CHROMOSOMAL-ABERRATIONS; CLASTOGENIC FACTORS; LYMPHOCYTES; EXPOSURE; PROGENY;

D O I：

10.1016/j.mrfmmm.2009.08.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The study of families irradiated as a result of the accident at the Chernobyl Nuclear Power Plant revealed significantly increased aberrant genomes frequencies (AGFs) not only in irradiated parents (n = 106 p < 0.01), but also in their children born after the accident (n = 159, p < 0.05). This is an indicative of the phenomenon of transgenerational genomic instability. To elucidate this phenomenon, experiments were undertaken to model genomic instability by using single and fractional in vitro gamma-irradiation (Cs-137) of peripheral blood samples from the children and their parents at doses of 0.1, 0.2 and 0.3 Gy. The spectrum and frequency of chromosome aberrations were studied in the 1st and 2nd cell generations. The average AGF was significantly increased at all doses (except 0.1 Gy) in children of irradiated parents, as compared to children born from non-irradiated parents. Amplification of cells with single-break chromosome aberrations in mitosis 2, as compared to mitosis 1, suggests the replication mechanism of realization of potential damage in DNA and the occurrence of genomic instability in succeeding cell generations. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：52 / 57

页数：6

共 48 条

[1] BALEVA LS, 2001, HLTH CHILDREN RAD PR, P224
[2] Radiation-induced transgenerational alterations in genome stability and DNA damage
Barber, R. C.
Hickenbotham, P.
Hatch, T.
Kelly, D.
Topchiy, N.
Almeida, G. M.
Jones, G. D. D.
Johnson, G. E.
Parry, J. M.
Rothkamm, K.
Dubrova, Y. E.
[J]. ONCOGENE, 2006, 25 (56) : 7336 - 7342
[3] The offspring of irradiated parents, are they stable?
Barber, Ruth C.
Dubrova, Yuri E.
[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2006, 598 (1-2) : 50 - 60
[4] BENNETT B, 2006, WHO HLTH EFFECTS CHE, P160
[5] BUCKTON K, 1976, METHOD HUMAN CHROMOS
[6] Burlakova E B, 1999, Radiats Biol Radioecol, V39, P26
[7] DUBININ NP, 1978, POTENTIAL CHANGES DN, P246
[8] Radiation-induced transgenerational instability
Dubrova, YE
[J]. ONCOGENE, 2003, 22 (45) : 7087 - 7093
[9] Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature
Fucic, A.
Brunborg, G.
Lasan, R.
Jezek, D.
Knudsen, L. E.
Merlof, D. F.
[J]. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2008, 658 (1-2) : 111 - 123
[10] Chromosome aberrations in lymphocytes and clastogenic factors in plasma detected in Belarus children 10 years after Chernobyl accident
Gemignani, F
Ballardin, M
Maggiani, F
Rossi, AM
Antonelli, A
Barale, R
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1999, 446 (02) : 245 - 253

← 1 2 3 4 5 →