Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: A review

被引：207

作者：

Anjum, Komal ^{[1
]}

Shagufta, Bibi Ibtesam ^{[2
]}

Abbas, Syed Qamar ^{[3
]}

Patel, Seema ^{[4
]}

Khan, Ishrat ^{[1
]}

Shah, Sayed Asmat Ali ^{[1
]}

Akhter, Najeeb ^{[1
]}

ul Hassan, Syed Shams ^{[5
]}

机构：

[1] Zhejiang Univ, Ocean Coll, Hangzhou 310058, Zhejiang, Peoples R China

[2] Kohat Univ Sci & Technol, Dept Zool, Kpk 26000, Pakistan

[3] Gomal Univ DI Khan, Fac Pharm, Kpk 29050, Pakistan

[4] San Diego State Univ, Bioinformat & Med Informat Res Ctr, San Diego, CA 92182 USA

[5] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 92卷

关键词：

GBM chemotherapy; FDA approved drugs; Natural anti-glioma; Synthetic anti-glioma; Novel anti-glioma; FATTY-ACID SYNTHASE; BEVACIZUMAB PLUS IRINOTECAN; PHASE-II TRIAL; CELL-DEATH; GLIOMA; TEMOZOLOMIDE; CANCER; EXPRESSION; APOPTOSIS; PROCARBAZINE;

D O I：

10.1016/j.biopha.2017.05.125

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glioblastoma multiforme (GBM) is the deadliest form of heterogeneous brain cancer. It affects an enormous number of patients every year and the survival is approximately 8 to 15 months. GBM has driven by complex signaling pathways and considered as a most challenging to treat. Standard treatment of GBM includes surgery, radiation therapy, chemotherapy and also the combined treatment. This review article described inter and intra-tumor heterogeneity of GMB. In addition, recent chemotherapeutic agents, with their mechanism of action have been defined. FDA-approved drugs also been focused over here and most importantly highlighting some natural and synthetic and novel anti-glioma agents, that are the main focus of researchers nowadays. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：681 / 689

页数：9

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