The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

被引：68
作者：
Bacanli, Merve [1 ]
Aydin, Sevtap [1 ]
Taner, Gokce [2 ]
Goktas, Hatice Gul [1 ,3 ]
Sahin, Tolga [4 ]
Basaran, A. Ahmet [5 ]
Basaran, Nursen [1 ]
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Toxicol, TR-06100 Ankara, Turkey
[2] Gazi Univ, Fac Sci, Dept Biol, TR-06500 Ankara, Turkey
[3] Cukurova Univ, Fac Pharm, Dept Pharmaceut Toxicol, TR-01330 Adana, Turkey
[4] Hacettepe Univ, Fac Kastamonu Med, Dept Surg, TR-06100 Ankara, Turkey
[5] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2014年 / 38卷 / 03期
关键词：
Sepsis; DNA damage; Alkaline single cell electrophoresis; Ferulic acid; INDUCED DNA-DAMAGE; CELLULAR STRESS-RESPONSE; GRAM-NEGATIVE SEPSIS; LIPID-PEROXIDATION; IN-VITRO; CECAL LIGATION; ANTIOXIDANT STATUS; HUMAN-LYMPHOCYTES; MITOCHONDRIAL DYSFUNCTION; COGNITIVE IMPAIRMENT;
D O I：
10.1016/j.etap.2014.08.018
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Ferulic acid (FA), a well-established natural antioxidant, has several pharmacological activities including anti-inflammatory, anticancer and hepatoprotective. This study aimed to investigate the effects of FA on sepsis-induced oxidative damage in Wistar albino rats. Sepsis-induced DNA damage in the lymphocytes, liver and kidney cells of rats were evaluated by comet assay with and without formamidopyrimidine DNA glycosylase (Fpg). The oxidative stress parameters such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and total glutathione (GSH) and malondialdehyde (MDA) levels were also measured. It is found that DNA damage in sepsis + FA-treated group was significantly lower than the sepsis group. FA treatment also decreased the MDA levels and increased the GSH levels and SOD and GSH-Px activities in the sepsis-induced rats. It seems that FA might have ameliorative effects against sepsis-induced oxidative damage. (C) 2014 Published by Elsevier B.V.
引用
收藏
页码：774 / 782
页数：9
相关论文
共 61 条
[41]   Protective effect of ferulic acid on γ-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes [J].
Prasad, NR ;
Srinivasan, A ;
Pugalendi, KV ;
Menon, VP .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2006, 603 (02) :129-134
[42]   Effects of diphenyl diselenide on oxidative stress induced by sepsis in rats [J].
Prauchner, Carlos A. ;
Prestes, Alessandro de S. ;
da Rocha, Joao B. T. .
PATHOLOGY RESEARCH AND PRACTICE, 2011, 207 (09) :554-558
[43]   Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice [J].
Ramar, Manikandan ;
Manikandan, Beulaja ;
Raman, Thiagarajan ;
Priyadarsini, Asokan ;
Palanisamy, Subramanian ;
Velayudam, Meiyalagan ;
Munusamy, Arumugam ;
Prabhu, Narayanan Marimuthu ;
Vaseeharan, Baskaralingam .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 690 (1-3) :226-235
[44]   Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation [J].
Ritter, C ;
Andrades, M ;
Frota, MLC ;
Bonatto, F ;
Pinho, RA ;
Polydoro, M ;
Klamt, F ;
Pinheiro, CTS ;
Menna-Barreto, SS ;
Moreira, JCF ;
Dal-Pizzol, F .
INTENSIVE CARE MEDICINE, 2003, 29 (10) :1782-1789
[45]   Cardioprotection with alcohol - Role of both alcohol and polyphenolic antioxidants [J].
Sato, M ;
Maulik, N ;
Das, DK .
ALCOHOL AND WINE IN HEALTH AND DISEASE, 2002, 957 :122-135
[46]   Glutathione, oxidative stress and neurodegeneration [J].
Schulz, JB ;
Lindenau, J ;
Seyfried, J ;
Dichgans, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (16) :4904-4911
[47]   Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma [J].
Sier, CFM ;
Kubben, FJGM ;
Ganesh, S ;
Heerding, MM ;
Griffioen, G ;
Hanemaaijer, R ;
vanKrieken, JHJM ;
Lamers, CBHW ;
Verspaget, HW .
BRITISH JOURNAL OF CANCER, 1996, 74 (03) :413-417
[48]   A SIMPLE TECHNIQUE FOR QUANTITATION OF LOW-LEVELS OF DNA DAMAGE IN INDIVIDUAL CELLS [J].
SINGH, NP ;
MCCOY, MT ;
TICE, RR ;
SCHNEIDER, EL .
EXPERIMENTAL CELL RESEARCH, 1988, 175 (01) :184-191
[49]   Influence of ferulic acid on γ-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes [J].
Srinivasan, M. ;
Sudheer, A. Ram ;
Pillai, K. Raveendran ;
Kumar, P. Raghu ;
Sudhakaran, P. R. ;
Menon, V. P. .
TOXICOLOGY, 2006, 228 (2-3) :249-258
[50]   Influence of ferulic acid on nicotine-induced lipid peroxidation, DNA damage and inflammation in experimental rats as compared to N-acetylcysteine [J].
Sudheer, Adluri Ram ;
Muthukumaran, Shanmugavel ;
Devipriya, Nagaraj An ;
Devaraj, Halagowder ;
Menon, Venugopal P. .
TOXICOLOGY, 2008, 243 (03) :317-329
1234567