Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice

被引：6

作者：

Wan, Zhong-xiao ^{[1
]}

Zhang, Feng ^{[1
]}

Geng, Qian ^{[1
]}

Wang, Pei-yu ^{[2
]}

Zhou, Hong ^{[3
]}

Zhang, Yu-mei ^{[1
]}

机构：

[1] Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China

[2] Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China

[3] Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China

来源：

INTERNATIONAL DAIRY JOURNAL | 2010年 / 20卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CYCLOPHOSPHAMIDE-TREATED MICE; IMMUNE-RESPONSE; T-CELLS; LYMPHOCYTES; LACTOFERRIN; PHASE; TRIAL; SUPPLEMENTATION; DISEASE; SYSTEM;

D O I：

10.1016/j.idairyj.2010.02.011

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Female ICR mice were administered with bovine colostrum and were treated with cyclophosphamide to establish immunosuppressed status. The cytokine levels in sera and splenocyte culture supernatants and splenic T cell subpopulations were determined. Bovine colostrum substantially restored the percentage of the total T cell population (CD3+) and effector CD4+ T lymphocyte, as well as influencing the CD4:CD8 ratio in the spleen. It was effective in increasing the concentrations of interleukin (IL)-2, interferon-gamma, granulocyte-macrophage colony-stimulating factor and decreasing the levels of IL-6 in vivo and in vitro. The levels of IL-10 in splenocyte culture supernatants were increased, whereas the levels of IL-4 in splenocyte culture supernatants were dramatically decreased. Moreover, bovine colostrum was efficacious in enhancing the production of IL-1 alpha in vitro. Thus, bovine colostrum could exhibit immunoregulatory effects via modulating splenic T lymphocytes subpopulations. Bovine colostrum may have pleiotropic effects on the production of cytokines in vivo and in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：522 / 527

页数：6

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