Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice

被引：6

作者：

Wan, Zhong-xiao ^{[1
]}

Zhang, Feng ^{[1
]}

Geng, Qian ^{[1
]}

Wang, Pei-yu ^{[2
]}

Zhou, Hong ^{[3
]}

Zhang, Yu-mei ^{[1
]}

机构：

[1] Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China

[2] Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China

[3] Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China

来源：

INTERNATIONAL DAIRY JOURNAL | 2010年 / 20卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CYCLOPHOSPHAMIDE-TREATED MICE; IMMUNE-RESPONSE; T-CELLS; LYMPHOCYTES; LACTOFERRIN; PHASE; TRIAL; SUPPLEMENTATION; DISEASE; SYSTEM;

D O I：

10.1016/j.idairyj.2010.02.011

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Female ICR mice were administered with bovine colostrum and were treated with cyclophosphamide to establish immunosuppressed status. The cytokine levels in sera and splenocyte culture supernatants and splenic T cell subpopulations were determined. Bovine colostrum substantially restored the percentage of the total T cell population (CD3+) and effector CD4+ T lymphocyte, as well as influencing the CD4:CD8 ratio in the spleen. It was effective in increasing the concentrations of interleukin (IL)-2, interferon-gamma, granulocyte-macrophage colony-stimulating factor and decreasing the levels of IL-6 in vivo and in vitro. The levels of IL-10 in splenocyte culture supernatants were increased, whereas the levels of IL-4 in splenocyte culture supernatants were dramatically decreased. Moreover, bovine colostrum was efficacious in enhancing the production of IL-1 alpha in vitro. Thus, bovine colostrum could exhibit immunoregulatory effects via modulating splenic T lymphocytes subpopulations. Bovine colostrum may have pleiotropic effects on the production of cytokines in vivo and in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：522 / 527

页数：6

共 45 条

[21] A novel extract from bovine colostrum whey supports anti-bacterial and anti-viral innate immune functions in vitro and in vivo I. Enhanced immune activity in vitro translates to improved microbial clearance in animal infection models [J].

Benson, Kathleen F. ;

Carter, Steve G. ;

Patterson, Kelly M. ;

Patel, Dilip ;

Jensen, Gitte S. .

PREVENTIVE MEDICINE, 2012, 54 :S116-S123

[22] Short communication: Effect of vitamins E and C on cortisol production by bovine adrenocortical cells in vitro [J].

Montalvo, C. P. ;

Diaz, N. H. ;

Gaidames, L. A. ;

Andres, M. E. ;

Larrain, R. E. .

JOURNAL OF DAIRY SCIENCE, 2011, 94 (07) :3495-3497

[23] Hyperimmune bovine colostrum containing lipopolysaccharide antibodies (IMM124-E) has a nondetrimental effect on gut microbial communities in unchallenged mice [J].

Gore, Rachele ;

Mohsenipour, Mitra ;

Wood, Jennifer L. ;

Balasuriya, Gayathri K. ;

Hill-Yardin, Elisa L. ;

Franks, Ashley E. .

INFECTION AND IMMUNITY, 2023, 91 (11)

[24] Effect of recombinant Panton-Valentine leukocidin in vitro on apoptosis and cytokine production of human alveolar macrophages [J].

Wu, Benquan ;

Zhang, Wenxian ;

Huang, Jing ;

Liu, Hui ;

Zhang, Tiantuo .

CANADIAN JOURNAL OF MICROBIOLOGY, 2010, 56 (03) :229-235

[25] IN VIVO EFFECT OF INSULIN ON THE HORMONE PRODUCTION OF IMMUNE CELLS IN MICE- GENDER DIFFERENCES [J].

Pallinger, Eva ;

Csaba, Gyoergy .

ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2014, 61 (04) :417-423

[26] L-citrulline Metabolism in Mice augments cD4+ T cell Proliferation and cytokine Production In Vitro, and accumulation in the Mycobacteria-infected lung [J].

Lange, Shannon M. ;

McKell, Melanie C. ;

Schmidt, Stephanie M. ;

Hossfeld, Austin P. ;

Chaturvedi, Vandana ;

Kinder, Jeremy M. ;

McAlees, Jaclyn W. ;

Lewkowich, Ian P. ;

Way, Sing Sing ;

Turner, Joanne ;

Qualls, Joseph E. .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[27] The Effect of Human Umbilical Cord Blood Cells on Survival and Cytokine Production by Post-Ischemic Astrocytes in Vitro [J].

Jiang, Lixian ;

Saporta, Samuel ;

Chen, Ning ;

Sanberg, Cyndy Davis ;

Sanberg, Paul ;

Willing, Alison .

STEM CELL REVIEWS AND REPORTS, 2010, 6 (04) :523-531

[28] Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo [J].

Neumann, E. ;

Ramos, M. G. ;

Santos, L. M. ;

Rodrigues, A. C. P. ;

Vieira, E. C. ;

Afonso, L. C. C. ;

Nicoli, J. R. ;

Vieira, L. Q. .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2009, 42 (04) :358-367

[29] The effect of in vivo exposure to zearalenone on cytokine secretion by Th1 and Th2 lymphocytes in porcine Peyer's patches after in vitro stimulation with LPS [J].

Obremski, K. .

POLISH JOURNAL OF VETERINARY SCIENCES, 2014, 17 (04) :625-632

[30] Suppression of Mesangial Cell Proliferation and Extracellular Matrix Production in Streptozotocin-Induced Diabetic Mice by Adiponectin In Vitro and In Vivo [J].

Huang, X. ;

Su, Y. -x. ;

Deng, H. -c. ;

Zhang, M. -x. ;

Long, J. ;

Peng, Z. -g. .

HORMONE AND METABOLIC RESEARCH, 2014, 46 (10) :736-743

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