Functional aspects of protein mono-ADP-ribosylation

被引：255

作者：

Corda, D ^{[1
]}

Di Girolamo, M ^{[1
]}

机构：

[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, I-66030 Santa Maria Imbaro, Chieti, Italy

来源：

EMBO JOURNAL | 2003年 / 22卷 / 09期

关键词：

ADP-ribosylhydrolase; ADP-ribosyltransferase; cell signalling; G proteins; post-translational modifications;

D O I：

10.1093/emboj/cdg209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mono-ADP-ribosylation is the enzymatic transfer of ADP-ribose from NAD(+) to acceptor proteins. It is catalysed by cellular ADP-ribosyltransferases and certain bacterial toxins. There are two subclasses of cellular enzymes: the ectoenzymes that modify targets such as integrins, defensin and other cell surface molecules; and the intracellular enzymes that act on proteins involved in cell signalling and metabolism, such as the beta-subunit of heterotrimeric G proteins, GRP78/BiP and elongation factor 2. The genes that encode the ectoenzymes have been cloned and their protein products are well characterized, yet little is known about the intracellular ADP-ribosyltransferases, which may be part of a novel protein family with an important role in regulating cell function. ADP-ribosylation usually leads to protein inactivation, providing a mechanism to inhibit protein functions in both physiological and pathological conditions.

引用

页码：1953 / 1958

页数：6

共 50 条

[1]

Bazan JF, 1997, ADV EXP MED BIOL, V419, P99

[2] Suppression of GTP/Tα-dependent activation of cGMP phosphodiesterase by ADP-ribosylation by its γ subunit in amphibian rod photoreceptor membranes [J].