Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses

被引:167
作者
Schmitz, D
Frerking, M
Nicoll, RA [1 ]
机构
[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0896-6273(00)00040-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Kainate receptors (KARs) are a poorly understood family of ionotropic glutamate receptors. A role for these receptors in the presynaptic control of transmitter release has been proposed but remains controversial. Here, KAR agonists are shown to enhance fiber excitability, and a number of experiments show that this is a direct effect of KARs on the presynaptic fibers. In addition, KAR activation inhibits evoked transmitter release from mossy fiber synapses. Synaptic release of glutamate from either neighboring mossy fiber synapses or associational/commisural (A/C) synapses results in the activation of these presynaptic ionotropic KARs. These results, along with previous studies, indicate that KARs, through the endogenous release of glutamate, mediate excitatory postsynaptic potentials (EPSPs), alter presynaptic excitability, and modulate transmitter release.
引用
收藏
页码:327 / 338
页数:12
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