The structure of insulin at the air/water interface: monomers or dimers?

被引：18
作者：
Mauri, S. [1 ,2 ]
Weidner, T. [2 ]
Arnolds, H. [1 ]
机构：
[1] Univ Liverpool, Surface Sci Res Ctr, Dept Chem, Liverpool L69 3BX, Merseyside, England
[2] Max Planck Inst Polymer Res, D-55128 Mainz, Germany
来源：
PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2014年 / 16卷 / 48期
关键词：
SUM-FREQUENCY GENERATION; VIBRATIONAL SPECTROSCOPY; AGGREGATION; VISUALIZATION; ORIENTATION; PEPTIDES; PROTEINS; DYNAMICS; SURFACES; KINETICS;
D O I：
10.1039/c4cp04926h
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The hydrophobic character of the air/water interface affects the oligomeric composition of insulin. By using interface-specific vibrational sum frequency spectroscopy and calculations of insulin monomer and dimer second-order nonlinear susceptibilities X-(2), we show that insulin monomers segregate to the air/water interface.
引用
收藏
页码：26722 / 26724
页数：3
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