Liquid Biopsy Biomarkers in Urine: A Route towards Molecular Diagnosis and Personalized Medicine of Bladder Cancer

被引：73

作者：

Ferro, Matteo ^{[1
]}

La Civita, Evelina ^{[2
]}

Liotti, Antonietta ^{[2
]}

Cennamo, Michele ^{[2
]}

Tortora, Fabiana ^{[3
]}

Buonerba, Carlo ^{[4
,5
]}

Crocetto, Felice ^{[6
]}

Lucarelli, Giuseppe ^{[7
]}

Busetto, Gian Maria ^{[8
]}

Del Giudice, Francesco ^{[9
]}

de Cobelli, Ottavio ^{[1
,10
]}

Carrieri, Giuseppe ^{[9
]}

Porreca, Angelo ^{[11
]}

Cimmino, Amelia ^{[12
]}

Terracciano, Daniela ^{[2
]}

机构：

[1] IRCCS, European Inst Oncol IEO, Dept Urol, Via Ripamonti 435, I-20141 Milan, Italy

[2] Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy

[3] CNR, Inst Prot Biochem, I-80131 Naples, Italy

[4] AOU Federico II, CRTR Rare Tumors Reference Ctr, I-80131 Naples, Italy

[5] Zoo Prophylact Inst Southern Italy, Environm & Hlth Operat Unit, I-80055 Portici, Italy

[6] Univ Naples Federico II, Dept Neurosci Sci Reprod & Odontostomatol, I-80131 Naples, Italy

[7] Univ Bari, Dept Emergency & Organ Transplantat, Urol Androl & Kidney Transplantat Unit, I-70124 Bari, Italy

[8] Univ Foggia, Dept Urol & Organ Transplantat, I-71122 Foggia, Italy

[9] Sapienza Univ Rome, Dept Urol, I-00185 Rome, Italy

[10] Univ Milan, Dipartimento Oncol & Ematoncol DIPO, I-20122 Milan, Italy

[11] Veneto Inst Oncol, Dept Urol, I-31033 Padua, Italy

[12] CNR, Inst Genet & Biophys, I-80131 Naples, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 03期

关键词：

bladder cancer; liquid biopsy; free nucleic acids; urinary biomarkers; LONG NONCODING RNAS; TRANSITIONAL-CELL CARCINOMA; TERT PROMOTER MUTATIONS; IN-SITU HYBRIDIZATION; UROSEEK GENE PANEL; UROTHELIAL CARCINOMA; DNA METHYLATION; FGFR3; MUTATIONS; MULTICENTER TRIAL; PROGNOSTIC VALUE;

D O I：

10.3390/jpm11030237

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Bladder cancer (BC) is characterized by high incidence and recurrence rates together with genomic instability and elevated mutation degree. Currently, cystoscopy combined with cytology is routinely used for diagnosis, prognosis and disease surveillance. Such an approach is often associated with several side effects, discomfort for the patient and high economic burden. Thus, there is an essential demand of non-invasive, sensitive, fast and inexpensive biomarkers for clinical management of BC patients. In this context, liquid biopsy represents a very promising tool that has been widely investigated over the last decade. Liquid biopsy will likely be at the basis of patient selection for precision medicine, both in terms of treatment choice and real-time monitoring of therapeutic effects. Several different urinary biomarkers have been proposed for liquid biopsy in BC, including DNA methylation and mutations, protein-based assays, non-coding RNAs and mRNA signatures. In this review, we summarized the state of the art on different available tests concerning their potential clinical applications for BC detection, prognosis, surveillance and response to therapy.

引用

页数：17

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