Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes

被引：2

作者：

Gnanapandithan, Karthik ^{[1
]}

Karthik, Nishrutha ^{[2
]}

Gerber, Jaime ^{[3
]}

机构：

[1] Mayo Clin, Dept Internal Med, 3500 San Pablo Rd S, Jacksonville, FL 32224 USA

[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Dept Cardiol, 333 Cedar St, New Haven, CT 06510 USA

来源：

CLINICS AND PRACTICE | 2021年 / 11卷 / 01期

关键词：

QT prolongation; Torsades de Pointes; metoclopramide; metronidazole; methadone; drug-induced Torsades de Pointes; INDUCED PROLONGATION; DRUG-THERAPY; QTC INTERVAL; ASSOCIATION; STATEMENT;

D O I：

10.3390/clinpract11010015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are several classes of medications that can cause prolongation of the corrected QT (QTc) interval and potentially Torsades de Pointes (TdP). Most of these medications are commonly used in the emergency department, and interaction between these medications increases the risk of this iatrogenic complication. We describe a patient on methadone therapy who developed TdP after she received metoclopramide and metronidazole. Interaction between different classes of medications can increase the risk of QTc prolongation and TdP. Awareness of this condition and its risk factors need continuous reinforcement among all hospital personnel to reduce the risk of this life-threatening complication.

引用

页码：101 / 105

页数：5

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