CD4+Foxp3+regulatory T lymphocytes expressing CD62L in patients with long-standing diabetes type 1

被引：0

作者：

Ryba, Monika ^{[1
]}

Hak, Lukasz ^{[1
]}

Zorena, Katarzyna ^{[1
]}

Mysliwiec, Malgorzata ^{[2
]}

Mysliwska, Jolanta ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Immunol, PL-80210 Gdansk, Poland

[2] Med Univ Gdansk, Clin Pediat Hematol Oncol & Endocrinol, Diabetol Dept, PL-80210 Gdansk, Poland

来源：

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 34卷 / 02期

关键词：

regulatory T cells; diabetes type 1; CD62L; Foxp3; L-SELECTIN; CELLS; FREQUENCY; MICE; SUBPOPULATION; MIGRATION; DEFECTS; FOXP3; GVHD;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diabetes type I is a chronic autoimmune disease in which insulin-producing cells located in the pancreatic islets of Langerhans are gradually destroyed by autoreactive T cells. Quantitative or qualitative dysfunctions in naturally arising CD4+Foxp3+ T lymphocytes may result in ineffective suppression of autoreactive T cells. CD62L is a surface molecule that plays role in homing capabilities of Tregs in autoimmunity if they must be present in the target tissue in order to have the proper effect. Only cells with high expression of CD62L are able to protect against diabetes. We investigated CD4+Foxp3+ cells expressing CD62L after in vitro stimulation with anti-CD3 from children with long-standing diabetes type I and we found lower frequencies of these cells in diabetic group compared to their healthy counterparts.

引用

页码：90 / 93

页数：4

共 19 条

[1] LYMPHOCYTE HOMING AND LEUKOCYTE ROLLING AND MIGRATION ARE IMPAIRED IN L-SELECTIN-DEFICIENT MICE [J].

ARBONES, ML ;

ORD, DC ;

LEY, K ;

RATECH, H ;

MAYNARDCURRY, C ;

OTTEN, G ;

CAPON, DJ ;

TEDDER, TF .

IMMUNITY, 1994, 1 (04) :247-260

[2] Tolerance to islet autoantigens in type 1 diabetes [J].

Bach, JF ;

Chatenoud, L .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :131-161

[3] Human CD4+CD25+ regulatory T cells [J].

Baecher-Allan, C ;

Viglietta, V ;

Hafler, DA .

SEMINARS IN IMMUNOLOGY, 2004, 16 (02) :89-97

[4] Functional defects and the influence of age on the frequency of CD4+CD25+ T-Cells in type 1 diabetes [J].

Brusko, TM ;

Wasserfall, CH ;

Clare-Salzler, MJ ;

Schatz, DA ;

Atkinson, MA .

DIABETES, 2005, 54 (05) :1407-1414

[5] No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes [J].

Brusko, Todd ;

Wasserfall, Clive ;

McGrail, Kieran ;

Schatz, Richard ;

Viener, Hina Lee ;

Schatz, Desmond ;

Haller, Michael ;

Rockell, Jennifer ;

Gottlieb, Peter ;

Clare-Salzler, Michael ;

Atkinson, Mark .

DIABETES, 2007, 56 (03) :604-612

[6] Human regulatory T cells: role in autoimmune disease and therapeutic opportunities [J].

Brusko, Todd M. ;

Putnam, Amy L. ;

Bluestone, Jeffrey A. .

IMMUNOLOGICAL REVIEWS, 2008, 223 :371-390

[7] Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD [J].

Ermann, J ;

Hoffmann, P ;

Edinger, M ;

Dutt, S ;

Blankenberg, FG ;

Higgins, JP ;

Negrin, RS ;

Fathman, CG ;

Strober, S .

BLOOD, 2005, 105 (05) :2220-2226

[8] Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].

Fontenot, Jason D. ;

Gavin, Marc A. ;

Rudensky, Alexander Y. .

JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992

[9] CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential [J].

Fu, S ;

Yopp, AC ;

Mao, X ;

Chen, DM ;

Zhang, N ;

Chen, D ;

Mao, MW ;

Ding, YZ ;

Bromberg, JS .

AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (01) :65-78

[10]

Genuth S, 2003, DIABETES CARE, V26, P3160

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