Sphingosine-1-phosphate: signaling inside and out

被引：239

作者：

Spiegel, S

Milstein, S

机构：

[1] Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20007 USA

[2] NIMH, Lab Cellular & Mol Regulat, NIH, Bethesda, MD 20892 USA

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

sphingosine-1-phosphate; EDG-1; sphingosine kinase; cell growth; apoptosis;

D O I：

10.1016/S0014-5793(00)01670-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors, which now includes EDG-1, -3, -5, -6 and -8, SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：55 / 57

页数：3

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