Efficient One-Pot Synthesis of Spirooxindole Derivatives by Ethylenediamine Diacetate Catalyzed Reactions in Water

被引：60

作者：

Hari, Galla Sri ^{[1
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn & Technol, Gyongsan 712749, South Korea

来源：

SYNTHESIS-STUTTGART | 2010年 / 03期

关键词：

spiro compounds; indoles; catalysis; Bronsted acids; Bronsted bases; water; MAMMALIAN-CELL CYCLE; PYRANOCHALCONE NATURAL-PRODUCTS; PUMMERER REACTION CHEMISTRY; CONCISE TOTAL-SYNTHESIS; DIELS-ALDER REACTIONS; ASPERGILLUS-FUMIGATUS; ASYMMETRIC-SYNTHESIS; CLAISEN REARRANGEMENT; TRYPROSTATIN-B; AQUEOUS-MEDIA;

D O I：

10.1055/s-0029-1217116

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling.

引用

页码：453 / 464

页数：12

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