Palladium catalyzed asymmetric allylic alkylation using chelating N-heterocyclic carbene-amino ligands

被引：24
|
作者：
Flahaut, Alexandre [1 ]
Roland, Sylvain [1 ]
Mangeney, Pierre [1 ]
机构：
[1] Univ Paris 06, Chim Organ Lab, UMR 7611, Inst Chim Mol,FR 2769, F-75252 Paris 05, France
来源：
TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 02期
关键词：
D O I：
10.1016/j.tetasy.2007.01.019
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Several silver(I) complexes with chiral amino-N-heterocyclic carbene (NHC) ligands, which are not diastereomerically pure, were prepared and used to generate in situ chelating NHC-amino palladiumt(II) complexes. The potential of these palladium(II) complexes in asymmetric catalysis was evaluated in the allylic alkylation reaction. The influence of the structure and of the diastereomeric purity of the ligands on enantio selectivity, as well as the role of the silver salts, were studied. Enantiomeric excesses of up to 80% were obtained with the best ligand. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：229 / 236
页数：8
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